DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryu, JH | ko |
dc.contributor.author | Lee, Y | ko |
dc.contributor.author | Kong, WH | ko |
dc.contributor.author | Kim, TG | ko |
dc.contributor.author | Park, TG | ko |
dc.contributor.author | Lee, Haeshin | ko |
dc.date.accessioned | 2013-03-09T09:48:38Z | - |
dc.date.available | 2013-03-09T09:48:38Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-07 | - |
dc.identifier.citation | BIOMACROMOLECULES, v.12, no.7, pp.2653 - 2659 | - |
dc.identifier.issn | 1525-7797 | - |
dc.identifier.uri | http://hdl.handle.net/10203/96024 | - |
dc.description.abstract | Bioinspired from adhesion behaviors of mussels, injectable and thermosensitive chitosan/Pluronic composite hydrogels were synthesized for tissue adhesives and hemostatic materials. Chitosan conjugated with multiple catechol groups in the backbone was cross-linked with terminally thiolated Pluronic F-127 triblock copolymer to produce temperature-sensitive and adhesive sol-gel transition hydrogels. A blend mixture of the catechol-conjugated chitosan and the thiolated Pluronic F-127 was a viscous solution state at room temperature but became a cross-linked gel state with instantaneous solidification at the body temperature and physiological pH. The adhesive chitosan/Pluronic injectable hydrogels with remnant catechol groups showed strong adhesiveness to soft tissues and mucous layers and also demonstrated superior hemostatic properties. These chitosan/Pluronic hydrogels are expected to be usefully exploited for injectable drug delivery depots, tissue engineering hydrogels, tissue adhesives, and antibleeding materials. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | PHOTOCROSSLINKABLE CHITOSAN | - |
dc.subject | MUSSEL ADHESION | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | QUINONES | - |
dc.subject | PROTEIN | - |
dc.subject | ACIDS | - |
dc.subject | OXIDATION | - |
dc.subject | RAT | - |
dc.title | Catechol-Functionalized Chitosan/Pluronic Hydrogels for Tissue Adhesives and Hemostatic Materials | - |
dc.type | Article | - |
dc.identifier.wosid | 000292617700027 | - |
dc.identifier.scopusid | 2-s2.0-79960235683 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 2653 | - |
dc.citation.endingpage | 2659 | - |
dc.citation.publicationname | BIOMACROMOLECULES | - |
dc.contributor.localauthor | Park, TG | - |
dc.contributor.localauthor | Lee, Haeshin | - |
dc.contributor.nonIdAuthor | Ryu, JH | - |
dc.contributor.nonIdAuthor | Lee, Y | - |
dc.contributor.nonIdAuthor | Kong, WH | - |
dc.contributor.nonIdAuthor | Kim, TG | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PHOTOCROSSLINKABLE CHITOSAN | - |
dc.subject.keywordPlus | MUSSEL ADHESION | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | QUINONES | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ACIDS | - |
dc.subject.keywordPlus | OXIDATION | - |
dc.subject.keywordPlus | RAT | - |
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