A Nonpeptidic Reverse-Turn Scaffold Stabilized by Urea-Based Dual Intramolecular Hydrogen Bonding
A novel nonpeptidic reverse-turn scaffold containing urea fragments that are connected by a conformationally constrained D-prolyl-cis-1,2-diaminocyclohexane (D-Pro-DACH) linker is reported. The scaffold adopts a well-defined reverse-turn conformation that is stabilized by dual intramolecular hydrogen bonding in both solution and solid states.
- Publisher
- AMER CHEMICAL SOC
- Issue Date
- 2011-07
- Language
- English
- Article Type
- Article
- Citation
ORGANIC LETTERS, v.13, no.13, pp.3486 - 3489
- ISSN
- 1523-7060
- Appears in Collection
- CH-Journal Papers(저널논문)
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