DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yoon Jung | ko |
dc.contributor.author | Moon, An Na | ko |
dc.contributor.author | Song, Jae Yang | ko |
dc.contributor.author | Kim, Eung Soo | ko |
dc.contributor.author | Kim, Chang Joon | ko |
dc.contributor.author | Chang, YongKeun | ko |
dc.date.accessioned | 2013-03-09T01:48:49Z | - |
dc.date.available | 2013-03-09T01:48:49Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-09 | - |
dc.identifier.citation | BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.14, no.5, pp.584 - 590 | - |
dc.identifier.issn | 1226-8372 | - |
dc.identifier.uri | http://hdl.handle.net/10203/95028 | - |
dc.description.abstract | In this study, transcriptional analyses by using reverse transcription-polymerase chain reaction (RT-PCR), DNA chip, and quantitative real time-PCR were performed to investigate effects of acidic pH shock on two-component systems in Streptomyces coelicolor A3(2). Two-component systems of cseC/cseB and vanS/vanR, known to be closely linked with self-protection against cell wall hydrolysis caused by external stimuli were upregulated by the pH shock. The chiS/chiR, afsQ2/afsQ1, ecrA2/ecrA1, bldM, ramC/ramR, and ragK/ragR known to be positively associated with the initiation of secondary metabolism were also upregulated. The cutS/cutR known to be negatively related to the secondary metabolism was, however, slightly downregulated. Upregulation or downregulation by the acidic pH shock of these two-component regulator systems might have contributed in a concerted manner to the enhancement of secondary metabolite production, at least, in this particular case of actinorhodin production in S. coelicolor A3(2). (C) KSBB | - |
dc.language | English | - |
dc.publisher | KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING | - |
dc.subject | SIGNAL-TRANSDUCTION SYSTEM | - |
dc.subject | SECONDARY METABOLISM | - |
dc.subject | MORPHOLOGICAL-DIFFERENTIATION | - |
dc.subject | KASUGAMYCIN PRODUCTION | - |
dc.subject | REGULATORY SYSTEM | - |
dc.subject | A3(2) | - |
dc.subject | ACTINORHODIN | - |
dc.subject | VANCOMYCIN | - |
dc.subject | RESISTANCE | - |
dc.subject | ANTIBIOTICS | - |
dc.title | Gene-expression Analysis of Acidic pH Shock Effects on Two-component Systems in Streptomyces coelicolor | - |
dc.type | Article | - |
dc.identifier.wosid | 000271405300006 | - |
dc.identifier.scopusid | 2-s2.0-70449687086 | - |
dc.type.rims | ART | - |
dc.citation.volume | 14 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 584 | - |
dc.citation.endingpage | 590 | - |
dc.citation.publicationname | BIOTECHNOLOGY AND BIOPROCESS ENGINEERING | - |
dc.identifier.doi | 10.1007/s12257-008-0260-8 | - |
dc.contributor.localauthor | Chang, YongKeun | - |
dc.contributor.nonIdAuthor | Kim, Eung Soo | - |
dc.contributor.nonIdAuthor | Kim, Chang Joon | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | pH shock | - |
dc.subject.keywordAuthor | Streptomyces coelicolor | - |
dc.subject.keywordAuthor | transcriptional analysis | - |
dc.subject.keywordAuthor | two-component system | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION SYSTEM | - |
dc.subject.keywordPlus | SECONDARY METABOLISM | - |
dc.subject.keywordPlus | MORPHOLOGICAL-DIFFERENTIATION | - |
dc.subject.keywordPlus | KASUGAMYCIN PRODUCTION | - |
dc.subject.keywordPlus | REGULATORY SYSTEM | - |
dc.subject.keywordPlus | A3(2) | - |
dc.subject.keywordPlus | ACTINORHODIN | - |
dc.subject.keywordPlus | VANCOMYCIN | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
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