This letter describes an optoelectrofluidic platform integrated with microfluidic channels for continuous generation and programmable manipulation of water-in-oil droplet emulsions. A microchannel was integrated into a film-based optoelectrofluidic device by selective perforation of poly(dimethylsiloxane) layer for simultaneously performing microfluidic generation and optoelectrofluidic manipulation of droplets in a single device. By using this device, we could continuously generate, interactively transport, and merge multiple droplets using optically induced virtual electrodes. (C) 2009 American Institute of Physics. [doi: 10.1063/1.3253411]