Phorbasones A and B Sesterterpenoids Isolated from the Marine Sponge Phorbas sp and Induction of Osteoblast Differentiation
Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral data and chemical reactions. Phorbasone A exhibited a positive effect on the calcium deposition activity in C3H10T1/2 cells. The biogenic origin of the core structure is believed to be through a novel rearrangement from the ansellone carbon structure.
- Publisher
- AMER CHEMICAL SOC
- Issue Date
- 2011-03
- Language
- English
- Article Type
- Article
- Keywords
NATURAL-PRODUCTS; STRUCTURE ELUCIDATION; DRUG DISCOVERY; DITERPENES; CONFIGURATIONS; PHORBOXAZOLE; MACROLIDES; CD
- Citation
ORGANIC LETTERS, v.13, no.5, pp.884 - 887
- ISSN
- 1523-7060
- Appears in Collection
- CH-Journal Papers(저널논문)
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