Chemical affinity matrix-based identification of prohibitin as a binding protein to anti-resorptive sulfonyl amidine compounds
In order to identify the binding proteins to anti-resorptive 5-chloro-1-(2,6-dimethylpiperidin-1-yl)-N-tosylpentan- 1-imine (1), the chemical affinity matrix for the compound 1 (2b) was designed and synthesized. Using 2b-based chemical proteomics, prohibitin was identified as one of strong binding proteins for 2b. (C) 2010 Elsevier Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Issue Date
- 2011-01
- Language
- English
- Article Type
- Article
- Keywords
ONE-POT SYNTHESIS; DIFFERENTIATION; ESTROGEN; FIMBRIN; WATER; OSTEOCLASTS; ALKYNE; AZIDES
- Citation
BIOORGANIC MEDICINAL CHEMISTRY LETTERS, v.21, no.2, pp.727 - 729
- ISSN
- 0960-894X
- Appears in Collection
- CH-Journal Papers(저널논문)
- Files in This Item
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