Cationic Lipid-Coated Gold Nanoparticles as Efficient and Non-Cytotoxic Intracellular siRNA Delivery Vehicles

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dc.contributor.authorKong, Won Hoko
dc.contributor.authorBae, Ki Hyunko
dc.contributor.authorJo, Sung Dukko
dc.contributor.authorKim, Jee Seonko
dc.contributor.authorPark, Tae Gwanko
dc.date.accessioned2013-03-08T16:12:48Z-
dc.date.available2013-03-08T16:12:48Z-
dc.date.created2012-03-05-
dc.date.created2012-03-05-
dc.date.issued2012-
dc.identifier.citationPHARMACEUTICAL RESEARCH, no.2, pp.362 - 374-
dc.identifier.issn0724-8741-
dc.identifier.urihttp://hdl.handle.net/10203/93530-
dc.description.abstractCationic lipid-coated gold nanoparticles were developed for efficient intracellular delivery of therapeutic siRNA. Particle formation was characterized by UV-visible spectroscopy, atomic force microscopy, and dynamic light scattering analysis. Cellular uptake, gene silencing effect, and cytotoxicity were investigated in multiple human cancer cell lines. Nanoparticles had a spherical nanostructure with highly cationic surface charge and could form stable nanosized polyelectrolyte complexes with siRNA via electrostatic interactions; complexes exhibited efficient intracellular uptake and significant gene silencing effect with markedly low cytotoxicity compared to the widely used polycationic carrier, linear polyethyleneimine. We demonstrated that cationic lipid-coated gold nanoparticles could be widely utilized as efficient and safe siRNA nanocarriers for diverse therapeutic and diagnostic applications.-
dc.languageEnglish-
dc.publisherSPRINGER/PLENUM PUBLISHERS-
dc.subjectSMALL-INTERFERING RNA-
dc.subjectGENE DELIVERY-
dc.subjectSYSTEMIC DELIVERY-
dc.subjectCONTRAST AGENT-
dc.subjectVEGF SIRNA-
dc.subjectPOLYELECTROLYTE-
dc.subjectTRANSFECTION-
dc.subjectSTRATEGIES-
dc.subjectDESIGN-
dc.subjectCANCER-
dc.titleCationic Lipid-Coated Gold Nanoparticles as Efficient and Non-Cytotoxic Intracellular siRNA Delivery Vehicles-
dc.typeArticle-
dc.identifier.wosid000299506700003-
dc.identifier.scopusid2-s2.0-84860875427-
dc.type.rimsART-
dc.citation.issue2-
dc.citation.beginningpage362-
dc.citation.endingpage374-
dc.citation.publicationnamePHARMACEUTICAL RESEARCH-
dc.identifier.doi10.1007/s11095-011-0554-y-
dc.contributor.localauthorPark, Tae Gwan-
dc.contributor.nonIdAuthorKong, Won Ho-
dc.contributor.nonIdAuthorJo, Sung Duk-
dc.contributor.nonIdAuthorKim, Jee Seon-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorcancer therapy-
dc.subject.keywordAuthorcationic lipid-
dc.subject.keywordAuthordelivery system-
dc.subject.keywordAuthorgold nanoparticle-
dc.subject.keywordAuthorsiRNA-
dc.subject.keywordPlusSMALL-INTERFERING RNA-
dc.subject.keywordPlusGENE DELIVERY-
dc.subject.keywordPlusSYSTEMIC DELIVERY-
dc.subject.keywordPlusCONTRAST AGENT-
dc.subject.keywordPlusVEGF SIRNA-
dc.subject.keywordPlusPOLYELECTROLYTE-
dc.subject.keywordPlusTRANSFECTION-
dc.subject.keywordPlusSTRATEGIES-
dc.subject.keywordPlusDESIGN-
dc.subject.keywordPlusCANCER-
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