DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kong, Won Ho | ko |
dc.contributor.author | Bae, Ki Hyun | ko |
dc.contributor.author | Jo, Sung Duk | ko |
dc.contributor.author | Kim, Jee Seon | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.date.accessioned | 2013-03-08T16:12:48Z | - |
dc.date.available | 2013-03-08T16:12:48Z | - |
dc.date.created | 2012-03-05 | - |
dc.date.created | 2012-03-05 | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | PHARMACEUTICAL RESEARCH, no.2, pp.362 - 374 | - |
dc.identifier.issn | 0724-8741 | - |
dc.identifier.uri | http://hdl.handle.net/10203/93530 | - |
dc.description.abstract | Cationic lipid-coated gold nanoparticles were developed for efficient intracellular delivery of therapeutic siRNA. Particle formation was characterized by UV-visible spectroscopy, atomic force microscopy, and dynamic light scattering analysis. Cellular uptake, gene silencing effect, and cytotoxicity were investigated in multiple human cancer cell lines. Nanoparticles had a spherical nanostructure with highly cationic surface charge and could form stable nanosized polyelectrolyte complexes with siRNA via electrostatic interactions; complexes exhibited efficient intracellular uptake and significant gene silencing effect with markedly low cytotoxicity compared to the widely used polycationic carrier, linear polyethyleneimine. We demonstrated that cationic lipid-coated gold nanoparticles could be widely utilized as efficient and safe siRNA nanocarriers for diverse therapeutic and diagnostic applications. | - |
dc.language | English | - |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | - |
dc.subject | SMALL-INTERFERING RNA | - |
dc.subject | GENE DELIVERY | - |
dc.subject | SYSTEMIC DELIVERY | - |
dc.subject | CONTRAST AGENT | - |
dc.subject | VEGF SIRNA | - |
dc.subject | POLYELECTROLYTE | - |
dc.subject | TRANSFECTION | - |
dc.subject | STRATEGIES | - |
dc.subject | DESIGN | - |
dc.subject | CANCER | - |
dc.title | Cationic Lipid-Coated Gold Nanoparticles as Efficient and Non-Cytotoxic Intracellular siRNA Delivery Vehicles | - |
dc.type | Article | - |
dc.identifier.wosid | 000299506700003 | - |
dc.identifier.scopusid | 2-s2.0-84860875427 | - |
dc.type.rims | ART | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 362 | - |
dc.citation.endingpage | 374 | - |
dc.citation.publicationname | PHARMACEUTICAL RESEARCH | - |
dc.identifier.doi | 10.1007/s11095-011-0554-y | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Kong, Won Ho | - |
dc.contributor.nonIdAuthor | Jo, Sung Duk | - |
dc.contributor.nonIdAuthor | Kim, Jee Seon | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cancer therapy | - |
dc.subject.keywordAuthor | cationic lipid | - |
dc.subject.keywordAuthor | delivery system | - |
dc.subject.keywordAuthor | gold nanoparticle | - |
dc.subject.keywordAuthor | siRNA | - |
dc.subject.keywordPlus | SMALL-INTERFERING RNA | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | SYSTEMIC DELIVERY | - |
dc.subject.keywordPlus | CONTRAST AGENT | - |
dc.subject.keywordPlus | VEGF SIRNA | - |
dc.subject.keywordPlus | POLYELECTROLYTE | - |
dc.subject.keywordPlus | TRANSFECTION | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | CANCER | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.