DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Eun-Hae | ko |
dc.contributor.author | Seo, Yeo-Jin | ko |
dc.contributor.author | Ahn, Hee-Chul | ko |
dc.contributor.author | Kang, Young-Min | ko |
dc.contributor.author | Kim, Hee-Eun | ko |
dc.contributor.author | Lee, Yeon-Mi | ko |
dc.contributor.author | Choi, Byong-Seok | ko |
dc.contributor.author | Lee, Joon-Hwa | ko |
dc.date.accessioned | 2013-03-08T15:42:28Z | - |
dc.date.available | 2013-03-08T15:42:28Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-11 | - |
dc.identifier.citation | FEBS LETTERS, v.584, no.21, pp.4453 - 4457 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://hdl.handle.net/10203/93452 | - |
dc.description.abstract | The Yaba-like disease viruses (YLDV) are members of the Yatapoxvirus family and have double-stranded DNA genomes. The E3L protein, which is essential for pathogenesis in the vaccinia virus, consists of two domains: an N-terminal Z-DNA binding domain and a C-terminal RNA binding domain. The crystal structure of the E3L orthologue of YLDV (yabZ alpha(E3L)) bound to Z-DNA revealed that the overall structure of yabZ alpha(E3L) and its interaction with Z-DNA are very similar to those of hZ alpha(ADAR1). Here we have performed NMR hydrogen exchange experiments on the complexes between yabZ alpha(E3L) and d(CGCGCG)(2) with a variety of protein-to-DNA molar ratios. This study revealed that yabZ alpha(E3L) could efficiently change the B-form helix of the d(CGCGCG)(2) to left-handed Z-DNA via the active-mono B-Z transition pathway like hZ alpha(ADAR1). (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | HANDED Z-DNA | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | PROTON-EXCHANGE | - |
dc.subject | HUMAN ADAR1 | - |
dc.subject | BINDING | - |
dc.subject | VIRUS | - |
dc.subject | SEQUENCE | - |
dc.subject | KINETICS | - |
dc.subject | REVEALS | - |
dc.subject | COMPLEX | - |
dc.title | NMR study of hydrogen exchange during the B-Z transition of a DNA duplex induced by the Z alpha domains of yatapoxvirus E3L | - |
dc.type | Article | - |
dc.identifier.wosid | 000283573100014 | - |
dc.identifier.scopusid | 2-s2.0-78049290009 | - |
dc.type.rims | ART | - |
dc.citation.volume | 584 | - |
dc.citation.issue | 21 | - |
dc.citation.beginningpage | 4453 | - |
dc.citation.endingpage | 4457 | - |
dc.citation.publicationname | FEBS LETTERS | - |
dc.identifier.doi | 10.1016/j.febslet.2010.10.003 | - |
dc.contributor.localauthor | Choi, Byong-Seok | - |
dc.contributor.nonIdAuthor | Lee, Eun-Hae | - |
dc.contributor.nonIdAuthor | Seo, Yeo-Jin | - |
dc.contributor.nonIdAuthor | Ahn, Hee-Chul | - |
dc.contributor.nonIdAuthor | Kang, Young-Min | - |
dc.contributor.nonIdAuthor | Kim, Hee-Eun | - |
dc.contributor.nonIdAuthor | Lee, Yeon-Mi | - |
dc.contributor.nonIdAuthor | Lee, Joon-Hwa | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | NMR | - |
dc.subject.keywordAuthor | Z-DNA | - |
dc.subject.keywordAuthor | Hydrogen exchange | - |
dc.subject.keywordAuthor | Z-DNA binding protein | - |
dc.subject.keywordAuthor | E3L | - |
dc.subject.keywordAuthor | Poxvirus | - |
dc.subject.keywordPlus | HANDED Z-DNA | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | PROTON-EXCHANGE | - |
dc.subject.keywordPlus | HUMAN ADAR1 | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | KINETICS | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | COMPLEX | - |
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