DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyejin | ko |
dc.contributor.author | Lee, Miae | ko |
dc.contributor.author | Lee, Sunhee | ko |
dc.contributor.author | Park, Byoungwoo | ko |
dc.contributor.author | Koh, Wansoo | ko |
dc.contributor.author | Lee, Dong Jun | ko |
dc.contributor.author | Lim, Dae-Sik | ko |
dc.contributor.author | Lee, Soojin | ko |
dc.date.accessioned | 2013-03-08T15:32:52Z | - |
dc.date.available | 2013-03-08T15:32:52Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-06 | - |
dc.identifier.citation | MOLECULES AND CELLS, v.27, no.6, pp.697 - 701 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | http://hdl.handle.net/10203/93427 | - |
dc.description.abstract | We previously identified cancer-upregulated gene 2 (CUG2) as a commonly up-regulated gene in various human cancer tissues, especially in ovary, liver, and lung (Lee et al., 2007a). CUG2 was determined to be a nuclear protein that exhibited high proto-oncogenic activities when overexpressed in NIH3T3 mouse fibroblast cells. To identify other cellular functions of CUG2, we performed yeast two-hybrid screening and identified CENP-T, a component of CENP-A nucleosome complex in the centromere, as an interacting partner of CUG2. Moreover, CENP-A, the principle centromeric determinant, was also found in complex with CENP-T/CUG2. Immunofluorescent staining revealed the co-localization of CUG2 with human centromeric markers. Inhibition of CUG2 expression drastically affected cell viability by inducing aberrant cell division. We propose that CUG2 is a new component of the human centromeric complex that is required for proper chromosome segregation during mitosis. | - |
dc.language | English | - |
dc.publisher | Korean Soc Molecular & Cellular Biology | - |
dc.subject | CHROMATIN | - |
dc.subject | ORGANIZATION | - |
dc.title | Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function | - |
dc.type | Article | - |
dc.identifier.wosid | 000267663600012 | - |
dc.identifier.scopusid | 2-s2.0-67650299735 | - |
dc.type.rims | ART | - |
dc.citation.volume | 27 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 697 | - |
dc.citation.endingpage | 701 | - |
dc.citation.publicationname | MOLECULES AND CELLS | - |
dc.identifier.doi | 10.1007/s10059-009-0083-2 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lim, Dae-Sik | - |
dc.contributor.nonIdAuthor | Kim, Hyejin | - |
dc.contributor.nonIdAuthor | Lee, Miae | - |
dc.contributor.nonIdAuthor | Lee, Sunhee | - |
dc.contributor.nonIdAuthor | Park, Byoungwoo | - |
dc.contributor.nonIdAuthor | Koh, Wansoo | - |
dc.contributor.nonIdAuthor | Lee, Soojin | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cancer-upregulated gene 2 | - |
dc.subject.keywordAuthor | CENP-A | - |
dc.subject.keywordAuthor | CENP-T | - |
dc.subject.keywordAuthor | centromere | - |
dc.subject.keywordAuthor | kinetochore | - |
dc.subject.keywordPlus | CHROMATIN | - |
dc.subject.keywordPlus | ORGANIZATION | - |
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