DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sung-Hong | ko |
dc.contributor.author | Masamoto, Kazuto | ko |
dc.contributor.author | Hendrich, Kristy | ko |
dc.contributor.author | Kanno, Twao | ko |
dc.contributor.author | Kim, Seong-Gi | ko |
dc.date.accessioned | 2013-03-08T14:06:28Z | - |
dc.date.available | 2013-03-08T14:06:28Z | - |
dc.date.created | 2012-06-21 | - |
dc.date.created | 2012-06-21 | - |
dc.date.issued | 2008-04 | - |
dc.identifier.citation | MAGNETIC RESONANCE IN MEDICINE, v.59, no.4, pp.855 - 865 | - |
dc.identifier.issn | 0740-3194 | - |
dc.identifier.uri | http://hdl.handle.net/10203/93206 | - |
dc.description.abstract | Rat brain vasculature was imaged at 9.4T with blood oxygenation level-dependent (BOLD) microscopy. Data were acquired without exogenous contrast agent in <35 min using 3D gradient-echo imaging with 78-mu m isotropic resolution. Detailed vascular patterns including intracortical veins and some branches were observed in simple magnitude-contrast data acquired at an experimentally optimized echo time. The venous origin of the dark patterns was confirmed by oxygenation-dependent studies, and when the systemic arterial oxygen saturation level was <80% BOLD microscopy revealed additional intracortical vessels presumed to be of arterial origin. Quantification shows a decrease of intracortical venous density with depth. The full width at half-minimum intensity was 90-190 mu m for most intracortical venous vessels identifiable by BOLD venography. Since actual diameters are not directly quantifiable by BOLD, we also measured diameter-dependent intracortical venous density in vivo by two-photon excitation fluorescent microscopy. Density comparisons between the two modalities, along with computer simulations, show that venous vessels as small as similar to 16-30 mu m diameter are detectable with 9.4T BOLD microscopy under our experimental conditions. | - |
dc.language | English | - |
dc.publisher | JOHN WILEY SONS INC | - |
dc.subject | DEPENDENT PHASE | - |
dc.subject | CONTRAST AGENT | - |
dc.subject | BLOOD-FLOW | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | RESOLUTION | - |
dc.subject | SIGNAL | - |
dc.subject | VESSELS | - |
dc.subject | FMRI | - |
dc.subject | MICROVASCULARITY | - |
dc.subject | CAPILLARIES | - |
dc.title | Imaging brain vasculature with BOLD microscopy: MR detection limits determined by in vivo two-photon microscopy | - |
dc.type | Article | - |
dc.identifier.wosid | 000254645500023 | - |
dc.identifier.scopusid | 2-s2.0-41849105422 | - |
dc.type.rims | ART | - |
dc.citation.volume | 59 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 855 | - |
dc.citation.endingpage | 865 | - |
dc.citation.publicationname | MAGNETIC RESONANCE IN MEDICINE | - |
dc.identifier.doi | 10.1002/mrm.21573 | - |
dc.contributor.localauthor | Park, Sung-Hong | - |
dc.contributor.nonIdAuthor | Masamoto, Kazuto | - |
dc.contributor.nonIdAuthor | Hendrich, Kristy | - |
dc.contributor.nonIdAuthor | Kanno, Twao | - |
dc.contributor.nonIdAuthor | Kim, Seong-Gi | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | venography | - |
dc.subject.keywordAuthor | microvasculature | - |
dc.subject.keywordAuthor | susceptibility-weighting | - |
dc.subject.keywordAuthor | BOLD | - |
dc.subject.keywordAuthor | high magnetic field | - |
dc.subject.keywordAuthor | two-photon microscopy | - |
dc.subject.keywordPlus | DEPENDENT PHASE | - |
dc.subject.keywordPlus | CONTRAST AGENT | - |
dc.subject.keywordPlus | BLOOD-FLOW | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | RESOLUTION | - |
dc.subject.keywordPlus | SIGNAL | - |
dc.subject.keywordPlus | VESSELS | - |
dc.subject.keywordPlus | FMRI | - |
dc.subject.keywordPlus | MICROVASCULARITY | - |
dc.subject.keywordPlus | CAPILLARIES | - |
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