DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, JI | ko |
dc.contributor.author | Kim, HS | ko |
dc.contributor.author | Lee, JR | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.contributor.author | Ryu, SH | ko |
dc.contributor.author | Suh, PG | ko |
dc.date.accessioned | 2013-03-08T11:28:17Z | - |
dc.date.available | 2013-03-08T11:28:17Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-04 | - |
dc.identifier.citation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.280, no.13, pp.12467 - 12473 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92908 | - |
dc.description.abstract | Phospholipase C-beta isozymes that are activated by G protein-coupled receptors ( GPCR) and heterotrimeric G proteins carry a PSD-95/Dlg/ZO-1 (PDZ) domain binding motif at their C terminus. Through interactions with PDZ domains, this motif may endow the PLC-beta isozyme with specific roles in GPCR signaling events that occur in compartmentalized regions of the plasma membrane. In this study, we identified the interaction of PLC-beta 3 with Shank2, a PDZ domain-containing multimodular scaffold in the postsynaptic density (PSD). The C terminus of PLC-beta 3, but not other PLC-beta isotypes, specifically interacts with the PDZ domain of Shank2. Homer 1b, a Shank-interacting protein that is linked to group I metabotropic glutamate receptors and IP3 receptors, forms a multiple complex with Shank2 and PLC-beta 3. Importantly, microinjection of a synthetic peptide specifically mimicking the C terminus of PLC-beta 3 markedly reduces the mGluR-mediated intracellular calcium response. These results demonstrate that Shank2 brings PLC-beta 3 closer to Homer 1b and constitutes an efficient mGluR-coupled signaling pathway in the PSD region of neuronal synapses. | - |
dc.language | English | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.subject | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject | POSTSYNAPTIC DENSITY | - |
dc.subject | SYNAPTIC PROTEINS | - |
dc.subject | INTRAMOLECULAR INTERACTION | - |
dc.subject | PDZ DOMAINS | - |
dc.subject | FAMILY | - |
dc.subject | BRAIN | - |
dc.subject | HOMER | - |
dc.subject | EXPRESSION | - |
dc.subject | COMPLEXES | - |
dc.title | The interaction of phospholipase C-beta 3 with Shank2 regulates mGluR-mediated calcium signal | - |
dc.type | Article | - |
dc.identifier.wosid | 000227922000050 | - |
dc.identifier.scopusid | 2-s2.0-16844362568 | - |
dc.type.rims | ART | - |
dc.citation.volume | 280 | - |
dc.citation.issue | 13 | - |
dc.citation.beginningpage | 12467 | - |
dc.citation.endingpage | 12473 | - |
dc.citation.publicationname | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.identifier.doi | 10.1074/jbc.M410740200 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Hwang, JI | - |
dc.contributor.nonIdAuthor | Kim, HS | - |
dc.contributor.nonIdAuthor | Lee, JR | - |
dc.contributor.nonIdAuthor | Ryu, SH | - |
dc.contributor.nonIdAuthor | Suh, PG | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | POSTSYNAPTIC DENSITY | - |
dc.subject.keywordPlus | SYNAPTIC PROTEINS | - |
dc.subject.keywordPlus | INTRAMOLECULAR INTERACTION | - |
dc.subject.keywordPlus | PDZ DOMAINS | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | HOMER | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | COMPLEXES | - |
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