DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Chunghun | ko |
dc.contributor.author | Chung, Brian Y. | ko |
dc.contributor.author | Pitman, Jena L. | ko |
dc.contributor.author | McGill, Jermaine J. | ko |
dc.contributor.author | Pradhan, Suraj | ko |
dc.contributor.author | Lee, Jongbin | ko |
dc.contributor.author | Keegan, Kevin P. | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.contributor.author | Allada, Ravi | ko |
dc.date.accessioned | 2013-03-08T11:17:55Z | - |
dc.date.available | 2013-03-08T11:17:55Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-06 | - |
dc.identifier.citation | CURRENT BIOLOGY, v.17, no.12, pp.1082 - 1089 | - |
dc.identifier.issn | 0960-9822 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92905 | - |
dc.description.abstract | Gene transcription is a central timekeeping process in animal clocks. In Drosophila, the basic helix-loop helix (bHLH)-PAS transcription-factor heterodimer, CLOCK/CYCLE (CLK/CYC), transcriptionally activates the clock components period (per), timeless (tim), Par domain protein 1 (Pdp1), and vrille (vri), which feed back and regulate distinct features of CLK/CYC function [1]. Microarray studies have identified numerous rhythmically expressed transcripts [2-7], some of which are potential direct CLK targets [7]. Here we demonstrate a circadian function for one such target, a bHLH-Orange repressor, CG17100/CLOCKWORK ORANGE (CWO). cwo is rhythmically expressed, and levels are reduced in Clk mutants, suggesting that cwo is CLK activated in vivo. cwo mutants display reduced-amplitude molecular and behavioral rhythms with lengthened periods. Molecular analysis suggests that CWO acts, in part, by repressing CLK target genes. We propose that CWO acts as a transcriptional and behavioral rhythm amplifier. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila | - |
dc.type | Article | - |
dc.identifier.wosid | 000247409000033 | - |
dc.identifier.scopusid | 2-s2.0-34250215964 | - |
dc.type.rims | ART | - |
dc.citation.volume | 17 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 1082 | - |
dc.citation.endingpage | 1089 | - |
dc.citation.publicationname | CURRENT BIOLOGY | - |
dc.identifier.doi | 10.1016/j.cub.2007.05.039 | - |
dc.contributor.localauthor | Lim, Chunghun | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Chung, Brian Y. | - |
dc.contributor.nonIdAuthor | Pitman, Jena L. | - |
dc.contributor.nonIdAuthor | McGill, Jermaine J. | - |
dc.contributor.nonIdAuthor | Pradhan, Suraj | - |
dc.contributor.nonIdAuthor | Lee, Jongbin | - |
dc.contributor.nonIdAuthor | Keegan, Kevin P. | - |
dc.contributor.nonIdAuthor | Allada, Ravi | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | SYSNEURO | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | PACEMAKER NEURONS | - |
dc.subject.keywordPlus | RHYTHMS | - |
dc.subject.keywordPlus | PERIOD | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | VRILLE | - |
dc.subject.keywordPlus | LOOP | - |
dc.subject.keywordPlus | OSCILLATORS | - |
dc.subject.keywordPlus | DOWNSTREAM | - |
dc.subject.keywordPlus | FEEDBACK | - |
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