DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ku, Bonsu | ko |
dc.contributor.author | Woo, Jae-Sung | ko |
dc.contributor.author | Liang, Chengyu | ko |
dc.contributor.author | Lee, Kwang-Hoon | ko |
dc.contributor.author | Jung, Jae U. | ko |
dc.contributor.author | Oh, Byung-Ha | ko |
dc.date.accessioned | 2013-03-08T10:59:56Z | - |
dc.date.available | 2013-03-08T10:59:56Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-05 | - |
dc.identifier.citation | AUTOPHAGY, v.4, no.4, pp.519 - 520 | - |
dc.identifier.issn | 1554-8627 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92872 | - |
dc.description.abstract | A multiprotein complex composed of Beclin 1, PI(3)KC3 and UVRAG promotes autophagosome formation, while this activity is suppressed by a cohort of antiapoptotic Bcl-2 family members. Recently, we showed that a viral Bcl-2 of murine gamma-herpesvirus 68, known as M 11, binds to Beclin 1 with markedly high affinity in comparison with cellular Bcl-2 or Bcl-X(L) that interacts with Beclin 1 weakly.(1) Furthermore, the binding affinity directly correlated with the potency of inhibition of autophagosome formation in cells. Herein, we present additional data showing that Beclin I forms a large homo-oligomer, and this oligornerization is partly disrupted by the binding of M11. Oligomerized Beclin 1 is proposed to serve as a platform enabling a concerted action of many molecules of the associating proteins, including Bif-1 that could be directly involved in autophagosome biogenesis on membranes owing to its BAR domain. | - |
dc.language | English | - |
dc.publisher | LANDES BIOSCIENCE | - |
dc.subject | AUTOPHAGY | - |
dc.subject | DOMAIN | - |
dc.subject | COMPLEX | - |
dc.subject | APOPTOSIS | - |
dc.subject | BINDING | - |
dc.subject | DEATH | - |
dc.subject | UVRAG | - |
dc.title | An insight into the mechanistic role of Beclin 1 and its inhibition by prosurvival Bcl-2 family proteins | - |
dc.type | Article | - |
dc.identifier.wosid | 000255904000019 | - |
dc.identifier.scopusid | 2-s2.0-43949139277 | - |
dc.type.rims | ART | - |
dc.citation.volume | 4 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 519 | - |
dc.citation.endingpage | 520 | - |
dc.citation.publicationname | AUTOPHAGY | - |
dc.contributor.localauthor | Oh, Byung-Ha | - |
dc.contributor.nonIdAuthor | Ku, Bonsu | - |
dc.contributor.nonIdAuthor | Woo, Jae-Sung | - |
dc.contributor.nonIdAuthor | Liang, Chengyu | - |
dc.contributor.nonIdAuthor | Lee, Kwang-Hoon | - |
dc.contributor.nonIdAuthor | Jung, Jae U. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | Beclin 1 | - |
dc.subject.keywordAuthor | Bcl-2 | - |
dc.subject.keywordAuthor | M 11 | - |
dc.subject.keywordAuthor | oligoincrization | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | UVRAG | - |
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