DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sik | ko |
dc.contributor.author | Kim, Won | ko |
dc.contributor.author | Kim, Duk Hoon | ko |
dc.contributor.author | Moon, Sang-Ok | ko |
dc.contributor.author | Jung, Yu Jin | ko |
dc.contributor.author | Lee, Ae Sin | ko |
dc.contributor.author | Kang, Kyung Pyo | ko |
dc.contributor.author | Jang, Kyu Yuri | ko |
dc.contributor.author | Lee, Sang Yong | ko |
dc.contributor.author | Sung, Mi Jeong | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Park, Sung Kwang | ko |
dc.date.accessioned | 2013-03-08T10:39:27Z | - |
dc.date.available | 2013-03-08T10:39:27Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | NEPHROLOGY DIALYSIS TRANSPLANTATION, v.23, no.9, pp.2784 - 2794 | - |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92852 | - |
dc.description.abstract | Background. Peritubular capillary injury induces chronic hypoxia in the renal tubulointerstitium, and renal peritubular capillary dysfunction is an early event that contributes to tubulointerstitial fibrosis. Cyclosporine A (CsA) is a potent immunosuppressant and improves survival of renal allografts. However, the limitation of CsA use is chronic nephrotoxicity. A soluble, stable and potent angiopoietin-1 (Ang1) variant, cartilage oligomeric matrix protein (COMP)-Ang1 has been developed. We investigated whether COMP-Ang1 ameliorates CsA-induced renal injury. Methods. CsA-treated mice were injected with recombinant adenovirus expressing either COMP-Ang1 or LacZ. Histology, inflammatory, haemodynamic and fibrotic parameters, and signalling pathway were evaluated. Results. Histologic examination showed that COMP-Ang1 significantly decreased CsA-induced tubular damage and tubulointerstitial fibrosis. CsA-induced increases in macrophage infiltration and expression of MCP-1 and ICAM-1 after CsA treatment were significantly reduced by COMP-Ang1. Treatment with COMP-Ang1 also decreased the CsA-induced increases in TGF-beta 1 and Smad 2/3 levels while increasing Smad 7 levels. Laser-Doppler sonographic findings and endothelial factor VIII staining revealed that COMP-Ang1 preserved the integrity of peritubular vasculature and intrarenal haemodynamics from the CsA-induced renal injury. COMP-Ang1 inhibited tubular cell apoptosis while increasing tubular cell proliferation in CsA-induced renal injury. Conclusions. These results indicate that COMP-Ang1 exhibited a protective effect on damaged peritubular capillaries, haemodynamic alteration and inflammation in CsA-induced renal injury. Thus, COMP-Ang1 may be useful as a therapeutic and prophylactic agent for specific protection against endothelial dysfunction and inflammation. | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | LEUKOCYTE ADHESION | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | LONG-TERM | - |
dc.subject | APOPTOSIS | - |
dc.subject | NEPHROTOXICITY | - |
dc.subject | CHEMOKINES | - |
dc.subject | EXPRESSION | - |
dc.subject | COMP-ANG1 | - |
dc.subject | DAMAGE | - |
dc.title | Protective effect of COMP-angiopoietin-1 on cyclosporine-induced renal injury in mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000259372400016 | - |
dc.identifier.scopusid | 2-s2.0-58549084583 | - |
dc.type.rims | ART | - |
dc.citation.volume | 23 | - |
dc.citation.issue | 9 | - |
dc.citation.beginningpage | 2784 | - |
dc.citation.endingpage | 2794 | - |
dc.citation.publicationname | NEPHROLOGY DIALYSIS TRANSPLANTATION | - |
dc.identifier.doi | 10.1093/ndt/gfn168 | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Lee, Sik | - |
dc.contributor.nonIdAuthor | Kim, Won | - |
dc.contributor.nonIdAuthor | Kim, Duk Hoon | - |
dc.contributor.nonIdAuthor | Moon, Sang-Ok | - |
dc.contributor.nonIdAuthor | Jung, Yu Jin | - |
dc.contributor.nonIdAuthor | Lee, Ae Sin | - |
dc.contributor.nonIdAuthor | Kang, Kyung Pyo | - |
dc.contributor.nonIdAuthor | Jang, Kyu Yuri | - |
dc.contributor.nonIdAuthor | Lee, Sang Yong | - |
dc.contributor.nonIdAuthor | Sung, Mi Jeong | - |
dc.contributor.nonIdAuthor | Park, Sung Kwang | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | COMP-angiopoietin-1 | - |
dc.subject.keywordAuthor | cyclosporine A | - |
dc.subject.keywordAuthor | endothelial cells | - |
dc.subject.keywordAuthor | renal fibrosis | - |
dc.subject.keywordPlus | LEUKOCYTE ADHESION | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | LONG-TERM | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | NEPHROTOXICITY | - |
dc.subject.keywordPlus | CHEMOKINES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | COMP-ANG1 | - |
dc.subject.keywordPlus | DAMAGE | - |
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