DC Field | Value | Language |
---|---|---|
dc.contributor.author | Morisada, T | ko |
dc.contributor.author | Oike, Y | ko |
dc.contributor.author | Yamada, Y | ko |
dc.contributor.author | Urano, T | ko |
dc.contributor.author | Akao, M | ko |
dc.contributor.author | Kubota, Y | ko |
dc.contributor.author | Maekawa, H | ko |
dc.contributor.author | Kimura, Y | ko |
dc.contributor.author | Ohmura, M | ko |
dc.contributor.author | Miyamoto, T | ko |
dc.contributor.author | Nozawa, S | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Alitalo, K | ko |
dc.contributor.author | Suda, T | ko |
dc.date.accessioned | 2013-03-08T10:30:59Z | - |
dc.date.available | 2013-03-08T10:30:59Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-06 | - |
dc.identifier.citation | BLOOD, v.105, no.12, pp.4649 - 4656 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92839 | - |
dc.description.abstract | Angiopoietin (Ang) signaling plays a role in angiogenesis and remodeling of blood vessels through the receptor tyrosine kinase Tie2, which is expressed on blood vessel endothelial cells (BECs). Recently it has been shown that Ang-2 is crucial for the formation of lymphatic vasculature and that defects in lymphangiogenesis seen in Ang-2 mutant mice are rescued by Ang-1. These findings suggest important roles for Ang signaling in the lymphatic vessel system; however, Ang function in lymphangiogenesis has not been characterized. In this study, we reveal that lymphatic vascular endothelial hyaluronan receptor 1-positive (LYVE-1(+)) lymphatic endothelial cells (LECs) express Tie2 in both embryonic and adult settings, indicating that Ang signaling occurs in lymphatic vessels. Therefore, we examined whether Ang-1 acts on in vivo lymphatic angiogenesis and in vitro growth of LECs. A chimeric form of Ang-1, cartilage oligomeric matrix protein (COMP)-Ang-1, promotes in vivo lymphatic angiogenesis in mouse cornea. Moreover, we found that COMP-Ang-1 stimulates in vitro colony formation of LECs. These Ang-1-induced in vivo and in vitro effects on LECs were suppressed by soluble Tie2-Fc fusion protein, which acts as an inhibitor by sequestering Ang-1. On the basis of these observations, we propose that Ang signaling regulates lymphatic vessel formation through Tie2. (c) 2005 by The American Society of Hematology. | - |
dc.language | English | - |
dc.publisher | AMER SOC HEMATOLOGY | - |
dc.subject | RECEPTOR TYROSINE KINASES | - |
dc.subject | GROWTH-FACTOR RECEPTOR-3 | - |
dc.subject | STEM-CELLS | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | VEGF RECEPTOR-3 | - |
dc.subject | TRANSGENIC MICE | - |
dc.subject | MOUSE CORNEA | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | LYMPHANGIOGENESIS | - |
dc.subject | EXPRESSION | - |
dc.title | Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation | - |
dc.type | Article | - |
dc.identifier.wosid | 000229757300026 | - |
dc.identifier.scopusid | 2-s2.0-20444414142 | - |
dc.type.rims | ART | - |
dc.citation.volume | 105 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 4649 | - |
dc.citation.endingpage | 4656 | - |
dc.citation.publicationname | BLOOD | - |
dc.identifier.doi | 10.1182/blood-2004-08-3382 | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Morisada, T | - |
dc.contributor.nonIdAuthor | Oike, Y | - |
dc.contributor.nonIdAuthor | Yamada, Y | - |
dc.contributor.nonIdAuthor | Urano, T | - |
dc.contributor.nonIdAuthor | Akao, M | - |
dc.contributor.nonIdAuthor | Kubota, Y | - |
dc.contributor.nonIdAuthor | Maekawa, H | - |
dc.contributor.nonIdAuthor | Kimura, Y | - |
dc.contributor.nonIdAuthor | Ohmura, M | - |
dc.contributor.nonIdAuthor | Miyamoto, T | - |
dc.contributor.nonIdAuthor | Nozawa, S | - |
dc.contributor.nonIdAuthor | Alitalo, K | - |
dc.contributor.nonIdAuthor | Suda, T | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | RECEPTOR TYROSINE KINASES | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR-3 | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | VEGF RECEPTOR-3 | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | MOUSE CORNEA | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | LYMPHANGIOGENESIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
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