DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jin, Heung Yong | ko |
dc.contributor.author | Piao, Ming Han | ko |
dc.contributor.author | Park, Ji Hyun | ko |
dc.contributor.author | Baek, Hong Sun | ko |
dc.contributor.author | Lee, Sik | ko |
dc.contributor.author | Kim, Won | ko |
dc.contributor.author | Park, Sung Kwang | ko |
dc.contributor.author | Kim, Chong Hwa | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Park, Tae Sun | ko |
dc.date.accessioned | 2013-03-08T10:01:21Z | - |
dc.date.available | 2013-03-08T10:01:21Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-08 | - |
dc.identifier.citation | CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, v.69, no.4, pp.343 - 355 | - |
dc.identifier.issn | 0011-393X | - |
dc.identifier.uri | http://hdl.handle.net/10203/92795 | - |
dc.description.abstract | BACKGROUND: Vascular and inflammatory processes have been reported to be factors in the pathogenesis of diabetic neuropathy. Angiopoietin-1 (Ang1) plays essential roles in regulating vascular growth, development, maturation, permeability, and inflammation. OBJECTIVE: The aim of this Study was to investigate the effect of cartilage oligomeric matrix protein (COMP)-Ang1, which is a Soluble, stable, potent Ang1 variant, on peripheral nerves in db/db diabetic mice. METHODS: The db/db diabetic mice were randomized into 2 groups based on their weight and glucose level and treated with recombinant adenovirus (Ade), expressing either COMP-Ang1 or the beta-galactosidase gene (LacZ) (control), for 8 weeks. Immunohistochemistry was performed using a polyclonal antibody of antiprotein gene product and a secondary antibody. Intraepidermal nerve fiber density (IENFD) was quantified as nerve fiber abundance per unit length of epidermis (IENF/mm). In addition, the total capillary length (TCL) per unit length of epidermis was summed (mm/mm(2)). All slides were coded and the capillary length and the number of nerve fibers were calculated by a blinded observer. RESULTS: Ten diabetic db/db mice (mean [SD] weight, 38.7 [195] g) were randomized to receive Ade-COMP-Ang1 or Ade-LacZ. IENFD was significantly greater in the Ade-COMP-Ang1 group compared with the Ade-LacZ group (mean [SD] 8.95 [3.30] vs 3.57 [0-73]/mm; P < 0.05). TCL was also significantly greater in the Ade-COMP-Ang1 group (2.79 [0.99] vs 2.04 (0.58] mrn/mm(2); P < 0.05). Compared with baseline, fasting blood glucose concentration after 8 weeks of treatment decreased significantly more In the Ade-COMP-Ang1 group than in the Ade-LacZ group (489 [45] to 361 [81] vs 495 [48] to 521 [70] mg/dL; P < 0.05). CONCLUSIONS: These results suggest that Ade-COMP-Ang1 might have had proliferative effects on peripheral nerve and cutaneous capillaries in this small animal study. Further investigation of the metabolic effect, target site, and related mediator of COMP-Ang1 is needed. | - |
dc.language | English | - |
dc.publisher | ELSEVIER | - |
dc.subject | GENE-TRANSFER | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | REPERFUSION INJURY | - |
dc.subject | RISK-FACTORS | - |
dc.subject | LONG-TERM | - |
dc.subject | NEUROPATHY | - |
dc.subject | RATS | - |
dc.subject | COMPLICATIONS | - |
dc.subject | DYSFUNCTION | - |
dc.subject | COMP-ANG1 | - |
dc.title | Effect of cartilage oligomeric matrix protein angiopoietin-1 on peripheral nerves in db/db diabetic mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000259313500005 | - |
dc.identifier.scopusid | 2-s2.0-51049105245 | - |
dc.type.rims | ART | - |
dc.citation.volume | 69 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 343 | - |
dc.citation.endingpage | 355 | - |
dc.citation.publicationname | CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL | - |
dc.identifier.doi | 10.1016/j.curtheres.2008.08.002 | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Jin, Heung Yong | - |
dc.contributor.nonIdAuthor | Piao, Ming Han | - |
dc.contributor.nonIdAuthor | Park, Ji Hyun | - |
dc.contributor.nonIdAuthor | Baek, Hong Sun | - |
dc.contributor.nonIdAuthor | Lee, Sik | - |
dc.contributor.nonIdAuthor | Kim, Won | - |
dc.contributor.nonIdAuthor | Park, Sung Kwang | - |
dc.contributor.nonIdAuthor | Kim, Chong Hwa | - |
dc.contributor.nonIdAuthor | Park, Tae Sun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | COMP-angiopoietin-1 | - |
dc.subject.keywordAuthor | db/db diabetic mice | - |
dc.subject.keywordAuthor | peripheral neuropathy | - |
dc.subject.keywordPlus | GENE-TRANSFER | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | REPERFUSION INJURY | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | LONG-TERM | - |
dc.subject.keywordPlus | NEUROPATHY | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | COMPLICATIONS | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | COMP-ANG1 | - |
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