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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

Interaction between the keratin cytoskeleton and eEF1B gamma affects protein synthesis in epithelial cells

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dc.contributor.authorKim, Seyunko
dc.contributor.authorKellner, Julianeko
dc.contributor.authorLee, Chang-Hunko
dc.contributor.authorCoulombe, Pierre A.ko
dc.date.accessioned2013-03-07T21:34:03Z-
dc.date.available2013-03-07T21:34:03Z-
dc.date.created2012-03-19-
dc.date.created2012-03-19-
dc.date.issued2007-10-
dc.identifier.citationNATURE STRUCTURAL MOLECULAR BIOLOGY, v.14, no.10, pp.982 - 983-
dc.identifier.issn1545-9985-
dc.identifier.urihttp://hdl.handle.net/10203/91413-
dc.description.abstractEukaryotic elongation factor-1 (eEF1) is essential for peptidechain elongation during translation. We report that its c subunit (eEF1B gamma) specifically binds, and bundles, keratin intermediate filaments. Disrupting this interaction depresses translation by similar to 20% and selectively increases 80S ribosomes in epithelial cells, an outcome recapitulated by RNA interference-mediated silencing of eEF1B gamma. These findings extend the emerging relationship between keratin proteins and the translational machinery.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectINTERMEDIATE FILAMENTS-
dc.subjectMECHANICAL-PROPERTIES-
dc.subjectACTIN CYTOSKELETON-
dc.subjectIDENTIFICATION-
dc.subjectDOMAIN-
dc.titleInteraction between the keratin cytoskeleton and eEF1B gamma affects protein synthesis in epithelial cells-
dc.typeArticle-
dc.identifier.wosid000250226700023-
dc.identifier.scopusid2-s2.0-34948845678-
dc.type.rimsART-
dc.citation.volume14-
dc.citation.issue10-
dc.citation.beginningpage982-
dc.citation.endingpage983-
dc.citation.publicationnameNATURE STRUCTURAL MOLECULAR BIOLOGY-
dc.identifier.doi10.1038/nsmb1301-
dc.contributor.localauthorKim, Seyun-
dc.contributor.nonIdAuthorKellner, Juliane-
dc.contributor.nonIdAuthorLee, Chang-Hun-
dc.contributor.nonIdAuthorCoulombe, Pierre A.-
dc.type.journalArticleArticle-
dc.subject.keywordPlusINTERMEDIATE FILAMENTS-
dc.subject.keywordPlusMECHANICAL-PROPERTIES-
dc.subject.keywordPlusACTIN CYTOSKELETON-
dc.subject.keywordPlusIDENTIFICATION-
dc.subject.keywordPlusDOMAIN-
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