DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Seung Rim | ko |
dc.contributor.author | Lee, Hyun Jin | ko |
dc.contributor.author | Kim, Jong-Duk | ko |
dc.date.accessioned | 2013-03-07T20:54:28Z | - |
dc.date.available | 2013-03-07T20:54:28Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-08 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v.114, no.1, pp.60 - 68 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | http://hdl.handle.net/10203/91297 | - |
dc.description.abstract | Direct conjugation of histidine to poly(2-hydroxyethyl aspartamide) (PHEA-His) and C-18-grafted PHEA (PHEA-g-C-18-His) was achieved via an ester linkage using N-alpha-BOC-L-histidine, followed by the deprotection of Boc groups. PHEA-His series would be expected as an endosomolytic synthetic polymer because of the buffering capacity at physiological and endosomal pH regulated by alpha-amine and imidazole groups in side chains. PHEA-g-C18-His series formed stable self-aggregates due to the hydrophobic interaction between grafted alkyl chains. The size, zeta potential, and micropolarity of PHEA-g-C-18-His series greatly increased at pH5.0, because aggregates swelled by a positive surface charge and the electrostatic repulsion of ionized histidine moieties in the aggregate surface. In the confocal microscopy, it was revealed that PHEA-g-C18-His was more uniformly distributed than PHEA-g-C-18 in HeLa cells after 8h of incubation and was attributed to the endosomolytic ability of conjugated histidine moieties. In doxorubicin-loaded self-aggregate systems, the histidine conjugation improved the cell cytotoxicity by a fast release of loaded doxorubicin at low pH and the endosomolytic ability of conjugated histidine, resulting in the easy nuclear access of doxorubicin. (c) 2006 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | POLY(2-HYDROXYETHYL ASPARTAMIDE) | - |
dc.subject | COPOLYMER MICELLES | - |
dc.subject | GENE DELIVERY | - |
dc.subject | TUMOR PH | - |
dc.subject | DESIGN | - |
dc.subject | POLYELECTROLYTE | - |
dc.subject | NANOPARTICLES | - |
dc.subject | CONSTRUCTS | - |
dc.subject | POLYMERS | - |
dc.subject | PEPTIDE | - |
dc.title | Histidine-conjugated poly(amino acid) derivatives for the novel endosomolytic delivery carrier of doxorubicin | - |
dc.type | Article | - |
dc.identifier.wosid | 000240052500006 | - |
dc.identifier.scopusid | 2-s2.0-33746584827 | - |
dc.type.rims | ART | - |
dc.citation.volume | 114 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 60 | - |
dc.citation.endingpage | 68 | - |
dc.citation.publicationname | JOURNAL OF CONTROLLED RELEASE | - |
dc.identifier.doi | 10.1016/j.jconrel.2006.05.016 | - |
dc.contributor.localauthor | Kim, Jong-Duk | - |
dc.contributor.nonIdAuthor | Yang, Seung Rim | - |
dc.contributor.nonIdAuthor | Lee, Hyun Jin | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | intracellular delivery | - |
dc.subject.keywordAuthor | endosomolytic synthetic polymer | - |
dc.subject.keywordAuthor | histidine | - |
dc.subject.keywordAuthor | doxorubicin | - |
dc.subject.keywordAuthor | poly(amino acids) | - |
dc.subject.keywordPlus | POLY(2-HYDROXYETHYL ASPARTAMIDE) | - |
dc.subject.keywordPlus | COPOLYMER MICELLES | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | TUMOR PH | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | POLYELECTROLYTE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | CONSTRUCTS | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | PEPTIDE | - |
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