DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Min Sup | ko |
dc.contributor.author | Song, Su Jung | ko |
dc.contributor.author | Kim, So Yeon | ko |
dc.contributor.author | Oh, Hyun Jung | ko |
dc.contributor.author | Lim, Dae-Sik | ko |
dc.date.accessioned | 2013-03-07T14:14:58Z | - |
dc.date.available | 2013-03-07T14:14:58Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-07 | - |
dc.identifier.citation | EMBO JOURNAL, v.27, no.13, pp.1863 - 1874 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | http://hdl.handle.net/10203/90374 | - |
dc.description.abstract | The tumour suppressor p53, which accumulates in response to DNA damage and induces cell-cycle arrest and apoptosis, has a key function in the maintenance of genome integrity. Under normal conditions, the antiproliferative effects of p53 are inhibited by MDM2, a ubiquitin ligase that promotes p53 ubiquitination and degradation. MDM2 is also self-ubiquitinated and degraded. Here, we show that the tumour suppressor RASSF1A regulates G1-S cell-cycle progression in a p53-dependent manner by promoting MDM2 self-ubiquitination and preventing p53 degradation. Importantly, RASSF1A associates with MDM2 and death-domain-associated protein (DAXX) in the nucleus, thereby disrupting the interactions between MDM2, DAXX, and the deubiquitinase, HAUSP, and enhancing the self-ubiquitin ligase activity of MDM2. Moreover, RASSF1A partially contributes to p53-dependent checkpoint activation at early time points in response to DNA damage. These findings reveal a new and important function for RASSF1A in regulating the p53-MDM2 pathway. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | ATM-DEPENDENT PHOSPHORYLATION | - |
dc.subject | RIBOSOMAL-PROTEIN L23 | - |
dc.subject | DNA-DAMAGE | - |
dc.subject | MICROTUBULE STABILITY | - |
dc.subject | P53 UBIQUITINATION | - |
dc.subject | BINDING PROTEIN | - |
dc.subject | DEGRADATION | - |
dc.subject | PATHWAY | - |
dc.subject | INHIBITION | - |
dc.subject | ACTIVATION | - |
dc.title | The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex | - |
dc.type | Article | - |
dc.identifier.wosid | 000257497000007 | - |
dc.identifier.scopusid | 2-s2.0-46949093338 | - |
dc.type.rims | ART | - |
dc.citation.volume | 27 | - |
dc.citation.issue | 13 | - |
dc.citation.beginningpage | 1863 | - |
dc.citation.endingpage | 1874 | - |
dc.citation.publicationname | EMBO JOURNAL | - |
dc.identifier.doi | 10.1038/emboj.2008.115 | - |
dc.contributor.localauthor | Lim, Dae-Sik | - |
dc.contributor.nonIdAuthor | Song, Min Sup | - |
dc.contributor.nonIdAuthor | Song, Su Jung | - |
dc.contributor.nonIdAuthor | Kim, So Yeon | - |
dc.contributor.nonIdAuthor | Oh, Hyun Jung | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | DAXX | - |
dc.subject.keywordAuthor | MDM2 | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | RASSF1A | - |
dc.subject.keywordPlus | ATM-DEPENDENT PHOSPHORYLATION | - |
dc.subject.keywordPlus | RIBOSOMAL-PROTEIN L23 | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | MICROTUBULE STABILITY | - |
dc.subject.keywordPlus | P53 UBIQUITINATION | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
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