DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yeo, S | ko |
dc.contributor.author | Lee, Kyung-Kwang | ko |
dc.contributor.author | Han, Yong Mahn | ko |
dc.contributor.author | Kang, Yong-Kook | ko |
dc.date.accessioned | 2013-03-07T14:02:30Z | - |
dc.date.available | 2013-03-07T14:02:30Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-12 | - |
dc.identifier.citation | MOLECULES AND CELLS, v.20, no.3, pp.423 - 428 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | http://hdl.handle.net/10203/90352 | - |
dc.description.abstract | Immediately after fertilization, a chromatin remodeling process in the oocyte cytoplasm extracts protamine molecules from the sperm-derived DNA and loads histones onto it. We examined how the histone H3-lysine 9 methylation system is established on the remodeled sperm chromatin in mice. We found that the paternal pronucleus was not stained for dimethylated H3-K9 (H3-m(2)K9) during pronucleus development, while the maternal genome stained intensively. Such H3-m(2)K9 asymmetry between the parental pronuclei was independent of HPIP localization and, much like DNA methylation, was preserved to the two-cell stage when the nucleus appeared to be compartmentalized for H3-m(2)K9. A conspicuous increase in H3-m(2)K9 level was observed at the four-cell stage, and then the level was maintained without a visible change up to the blastocyst stage. The behavior of H3-m(2)K9 was very similar, but not identical, to that of 5-methylcytosine during preimplantation development, suggesting that there is some connection between methylation of histone and of DNA in early mouse development. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.subject | DNA METHYLATION | - |
dc.subject | MAMMALIAN DEVELOPMENT | - |
dc.subject | PATERNAL GENOME | - |
dc.subject | CHROMATIN | - |
dc.subject | DEMETHYLATION | - |
dc.subject | METHYLTRANSFERASES | - |
dc.subject | HETEROCHROMATIN | - |
dc.subject | CHROMOSOME | - |
dc.subject | REPRESSION | - |
dc.subject | OOCYTES | - |
dc.title | Methylation changes of lysine 9 of histone H3 during preimplantation mouse development | - |
dc.type | Article | - |
dc.identifier.wosid | 000234426600017 | - |
dc.identifier.scopusid | 2-s2.0-33644870416 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 423 | - |
dc.citation.endingpage | 428 | - |
dc.citation.publicationname | MOLECULES AND CELLS | - |
dc.contributor.localauthor | Han, Yong Mahn | - |
dc.contributor.nonIdAuthor | Yeo, S | - |
dc.contributor.nonIdAuthor | Lee, Kyung-Kwang | - |
dc.contributor.nonIdAuthor | Kang, Yong-Kook | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | active demethylation | - |
dc.subject.keywordAuthor | DNA methylation | - |
dc.subject.keywordAuthor | epigenetic reprogramming | - |
dc.subject.keywordAuthor | histone methylation | - |
dc.subject.keywordAuthor | preimplantation embryo | - |
dc.subject.keywordAuthor | pronucleus | - |
dc.subject.keywordPlus | DNA METHYLATION | - |
dc.subject.keywordPlus | MAMMALIAN DEVELOPMENT | - |
dc.subject.keywordPlus | PATERNAL GENOME | - |
dc.subject.keywordPlus | CHROMATIN | - |
dc.subject.keywordPlus | DEMETHYLATION | - |
dc.subject.keywordPlus | METHYLTRANSFERASES | - |
dc.subject.keywordPlus | HETEROCHROMATIN | - |
dc.subject.keywordPlus | CHROMOSOME | - |
dc.subject.keywordPlus | REPRESSION | - |
dc.subject.keywordPlus | OOCYTES | - |
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