Neuronal competition and selection during memory formation

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Competition between neurons is necessary for refining neural circuits during development and may be important for selecting the neurons that participate in encoding memories in the adult brain. To examine neuronal competition during memory formation, we conducted experiments with mice in which we manipulated the function of CREB ( adenosine 3',5'-monophosphate response element-binding protein) in subsets of neurons. Changes in CREB function influenced the probability that individual lateral amygdala neurons were recruited into a fear memory trace. Our results suggest a competitive model underlying memory formation, in which eligible neurons are selected to participate in a memory trace as a function of their relative CREB activity at the time of learning.
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Issue Date
2007-04
Language
English
Article Type
Article
Keywords

ELEMENT-BINDING PROTEIN; LONG-TERM-MEMORY; FEAR MEMORIES; IN-VIVO; AMYGDALA; CREB; EXPRESSION; OVEREXPRESSION; PLASTICITY; ACTIVATOR

Citation

SCIENCE, v.316, no.5823, pp.457 - 460

ISSN
0036-8075
DOI
10.1126/science.1139438
URI
http://hdl.handle.net/10203/90347
Appears in Collection
BS-Journal Papers(저널논문)
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