DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jin Woo | ko |
dc.contributor.author | Kim, Myung Jin | ko |
dc.contributor.author | Kim, Kwang Je | ko |
dc.contributor.author | Yun, Hee Jae | ko |
dc.contributor.author | Chae, Ji Soo | ko |
dc.contributor.author | Hwang, Sang Gil | ko |
dc.contributor.author | Chang, Tong-Shin | ko |
dc.contributor.author | Park, Hee-Sae | ko |
dc.contributor.author | Lee, Kang-Woo | ko |
dc.contributor.author | Han, Pyung-Lim | ko |
dc.contributor.author | Cho, Ssang-Goo | ko |
dc.contributor.author | Kim, Tae-Wan | ko |
dc.contributor.author | Choi, Eui-Ju | ko |
dc.date.accessioned | 2013-03-07T13:33:54Z | - |
dc.date.available | 2013-03-07T13:33:54Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-10 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.102, no.40, pp.14308 - 14313 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/90296 | - |
dc.description.abstract | The transmembrane protein Notch is cleaved by gamma-secretase to yield an active form, Notch intracellular domain (Notch-IC), in response to the binding of ligands, such as Jagged. Notch-IC contributes to the regulation of a variety of cellular events, including cell fate determination during embryonic development as well as cell growth, differentiation, and survival. We now show that Notch1-IC suppresses the scaffold activity of c-Jun N-terminal kinase (JNK)-interacting protein 1 (JIP1) in the JNK signaling pathway. Notch1-IC physically associated with the JNK binding domain of JlP1 and thereby interfered with the interaction between JlP1 and JNK. JlP1 mediated the activation of JNK1 induced by glucose deprivation in mouse embryonic fibroblasts, and ectopic expression of Notch1-IC inhibited JNK activation and apoptosis triggered by glucose deprivation. Taken together, these findings suggest that Notch1-IC negatively regulates the JNK pathway by disrupting the scaffold function of JIP1. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | KINASE CASCADES | - |
dc.subject | STRESS | - |
dc.subject | TRANSDUCTION | - |
dc.subject | ACTIVATION | - |
dc.subject | PRESENILIN | - |
dc.subject | CLEAVAGE | - |
dc.subject | CELLS | - |
dc.subject | SUPPRESSOR | - |
dc.subject | DROSOPHILA | - |
dc.subject | BRAIN | - |
dc.title | Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathway | - |
dc.type | Article | - |
dc.identifier.wosid | 000232392900035 | - |
dc.identifier.scopusid | 2-s2.0-26444435322 | - |
dc.type.rims | ART | - |
dc.citation.volume | 102 | - |
dc.citation.issue | 40 | - |
dc.citation.beginningpage | 14308 | - |
dc.citation.endingpage | 14313 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.0501600102 | - |
dc.contributor.localauthor | Kim, Jin Woo | - |
dc.contributor.nonIdAuthor | Kim, Myung Jin | - |
dc.contributor.nonIdAuthor | Kim, Kwang Je | - |
dc.contributor.nonIdAuthor | Yun, Hee Jae | - |
dc.contributor.nonIdAuthor | Chae, Ji Soo | - |
dc.contributor.nonIdAuthor | Hwang, Sang Gil | - |
dc.contributor.nonIdAuthor | Chang, Tong-Shin | - |
dc.contributor.nonIdAuthor | Park, Hee-Sae | - |
dc.contributor.nonIdAuthor | Lee, Kang-Woo | - |
dc.contributor.nonIdAuthor | Han, Pyung-Lim | - |
dc.contributor.nonIdAuthor | Cho, Ssang-Goo | - |
dc.contributor.nonIdAuthor | Kim, Tae-Wan | - |
dc.contributor.nonIdAuthor | Choi, Eui-Ju | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | scaffold | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | glucose deprivation | - |
dc.subject.keywordPlus | KINASE CASCADES | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PRESENILIN | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | SUPPRESSOR | - |
dc.subject.keywordPlus | DROSOPHILA | - |
dc.subject.keywordPlus | BRAIN | - |
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