DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, K | ko |
dc.contributor.author | Choi, Chulhee | ko |
dc.date.accessioned | 2013-03-07T13:23:08Z | - |
dc.date.available | 2013-03-07T13:23:08Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-04 | - |
dc.identifier.citation | JOURNAL OF NEUROCHEMISTRY, v.105, pp.557 - 564 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.uri | http://hdl.handle.net/10203/90275 | - |
dc.description.abstract | Caffeic acid phenethyl ester (CAPE), an active component of propolis extracts, has been known for its specific inhibition of nuclear factor kappa B (NF-kappa B) and subsequent anti-inflammatory activity. In this study, we report that (i) CAPE exerts its anti-inflammatory action (inhibition of tumor necrosis factor-induced expression of intercellular adhesion molecule-1 and CC chemokine ligand-2) via NF-kappa B inhibition by two distinct molecular mechanisms in a cell-specific manner: CAPE inhibited downstream pathways of inhibitor kappa B (I kappa B) degradation in monocytic cells, while activation of upstream I kappa B kinase was suppressed by CAPE pre-treatment in astroglial cells; and (ii) CAPE paradoxically activates the c-Jun N-terminal kinase (JNK) pathway, which might be responsible for its pro-apoptotic action and divergent regulation of proinflammatory mediators such as CXC chemokine ligand-8. | - |
dc.language | English | - |
dc.publisher | BLACKWELL PUBLISHING | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | HUMAN ASTROCYTES | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | IMMUNE FUNCTION | - |
dc.subject | NUCLEAR-FACTOR | - |
dc.subject | TNF-ALPHA | - |
dc.subject | ACTIVATION | - |
dc.subject | APOPTOSIS | - |
dc.subject | FAS | - |
dc.subject | TRANSCRIPTION | - |
dc.title | Differential regulation of c-Jun N-terminal kinase and NF-kappa B pathway by caffeic acid phenethyl ester in astroglial and monocytic cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000254615100024 | - |
dc.identifier.scopusid | 2-s2.0-41749102649 | - |
dc.type.rims | ART | - |
dc.citation.volume | 105 | - |
dc.citation.beginningpage | 557 | - |
dc.citation.endingpage | 564 | - |
dc.citation.publicationname | JOURNAL OF NEUROCHEMISTRY | - |
dc.identifier.doi | 10.1111/j.1471-4159.2007.05193.x | - |
dc.contributor.localauthor | Choi, Chulhee | - |
dc.contributor.nonIdAuthor | Choi, K | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | astroglial cell | - |
dc.subject.keywordAuthor | caffeic acid phenethyl ester | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | JNK | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | HUMAN ASTROCYTES | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | IMMUNE FUNCTION | - |
dc.subject.keywordPlus | NUCLEAR-FACTOR | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | FAS | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
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