DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liang, Chengyu | ko |
dc.contributor.author | Feng, Pinghui | ko |
dc.contributor.author | Ku, Bonsu | ko |
dc.contributor.author | Oh, Byung-Ha | ko |
dc.contributor.author | Jung, Jae U. | ko |
dc.date.accessioned | 2013-03-07T11:56:52Z | - |
dc.date.available | 2013-03-07T11:56:52Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-01 | - |
dc.identifier.citation | AUTOPHAGY, v.3, no.1, pp.69 - 71 | - |
dc.identifier.issn | 1554-8627 | - |
dc.identifier.uri | http://hdl.handle.net/10203/90117 | - |
dc.description.abstract | Autophagy has a well-documented role in the maintenance of homeostasis and the response to stressful environments and it is often deregulated in various human diseases including cancer. The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway. Previous studies(1) have demonstrated that Beclin 1-PI3KC3-mediated autophagy is negatively regulated by a proto-oncogene Bcl-2. We have recently identified a novel coiled-coil UVRAG tumor suppressor candidate, which positively engages in Beclin 1-dependent autophagy. UVRAG interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenesis. This finding adds a new player to the emerging picture of the autophagy network, underscoring the importance of the coordinated activity between Bcl-2 and UVRAG in the regulation of Beclin 1-PI3KC3-mediated autophagy and tumor cell control. | - |
dc.language | English | - |
dc.publisher | LANDES BIOSCIENCE | - |
dc.subject | COLON-CANCER | - |
dc.subject | GENE | - |
dc.subject | BECLIN-1 | - |
dc.subject | INHIBITION | - |
dc.subject | SUPPRESSOR | - |
dc.subject | PROTEIN | - |
dc.subject | CLONING | - |
dc.title | UVRAG - A new player in autophagy and tumor cell growth | - |
dc.type | Article | - |
dc.identifier.wosid | 000243499200021 | - |
dc.identifier.scopusid | 2-s2.0-33846204370 | - |
dc.type.rims | ART | - |
dc.citation.volume | 3 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 69 | - |
dc.citation.endingpage | 71 | - |
dc.citation.publicationname | AUTOPHAGY | - |
dc.contributor.localauthor | Oh, Byung-Ha | - |
dc.contributor.nonIdAuthor | Liang, Chengyu | - |
dc.contributor.nonIdAuthor | Feng, Pinghui | - |
dc.contributor.nonIdAuthor | Ku, Bonsu | - |
dc.contributor.nonIdAuthor | Jung, Jae U. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | UVRAG | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | tumor suppression | - |
dc.subject.keywordAuthor | Beclin 1 | - |
dc.subject.keywordAuthor | Bcl-2 | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | BECLIN-1 | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | SUPPRESSOR | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CLONING | - |
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