Efficient enantioselective synthesis of alpha-hydroxy-beta-amino acids using the claisen and curtius rearrangements

Abstract

Highly enantioselective and facile synthesis of a-hydroxy-p-amino acids has been achieved using the Claisen and Curtius rearrangements as key reactions. Chiral allylic alcohols were employed, which can be prepared by asymmetric catalysis in both E- and Z-forms; both anti- and syn-alpha-hydroxy-beta-amino acids have been synthesized.