DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, HM | ko |
dc.contributor.author | Hong, SH | ko |
dc.contributor.author | Kim, MS | ko |
dc.contributor.author | Lee, CW | ko |
dc.contributor.author | Kang, JS | ko |
dc.contributor.author | Lee, K | ko |
dc.contributor.author | Park, SK | ko |
dc.contributor.author | Han, JW | ko |
dc.contributor.author | Lee, Hee Yoon | ko |
dc.contributor.author | Choi, Y | ko |
dc.contributor.author | Kwon, HJ | ko |
dc.contributor.author | Han, G | ko |
dc.date.accessioned | 2013-03-07T08:50:52Z | - |
dc.date.available | 2013-03-07T08:50:52Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-11 | - |
dc.identifier.citation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.72, pp.6234 - 6238 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | http://hdl.handle.net/10203/89826 | - |
dc.description.abstract | Novel delta-lactam-based HDAC inhibitors which have various substituted benzyl, bi-aromatic cap groups were prepared using ring closure metathesis reaction, and evaluated their HDAC inhibitory activities and anti-proliferative effects. Among prepared analogues, 11m and 11o have very strong HDAC enzymatic inhibition and showed the most potent growth inhibitory activity to five human tumor cell lines including PC-3, ACHN, NUGC-3, HCT-15, and MBA-MB-231 tumor cell lines. Compounds 11m and 11o also showed good tumor growth inhibition of MDA-MB-231 cells in in vivo xenograft model. Structure-activity relationship study using docking model explained the significance of hydrophobic aromatic cap groups for their in vitro activities. (C) 2007 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | PROLIFERATION | - |
dc.subject | GROWTH | - |
dc.subject | CELLS | - |
dc.title | Modification of cap group in delta-lactam-based histone deacetylase (HDAC) inhibitors | - |
dc.type | Article | - |
dc.identifier.wosid | 000250906200039 | - |
dc.identifier.scopusid | 2-s2.0-35148888600 | - |
dc.type.rims | ART | - |
dc.citation.volume | 17 | - |
dc.citation.issue | 72 | - |
dc.citation.beginningpage | 6234 | - |
dc.citation.endingpage | 6238 | - |
dc.citation.publicationname | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.identifier.doi | 10.1016/j.bmcl.2007.09.034 | - |
dc.contributor.localauthor | Lee, Hee Yoon | - |
dc.contributor.nonIdAuthor | Kim, HM | - |
dc.contributor.nonIdAuthor | Hong, SH | - |
dc.contributor.nonIdAuthor | Kim, MS | - |
dc.contributor.nonIdAuthor | Lee, CW | - |
dc.contributor.nonIdAuthor | Kang, JS | - |
dc.contributor.nonIdAuthor | Lee, K | - |
dc.contributor.nonIdAuthor | Park, SK | - |
dc.contributor.nonIdAuthor | Han, JW | - |
dc.contributor.nonIdAuthor | Choi, Y | - |
dc.contributor.nonIdAuthor | Kwon, HJ | - |
dc.contributor.nonIdAuthor | Han, G | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | histone deacetylase | - |
dc.subject.keywordAuthor | HDAC | - |
dc.subject.keywordAuthor | anticancer chemotherapy | - |
dc.subject.keywordAuthor | enzyme inhibitor | - |
dc.subject.keywordAuthor | growth inhibition | - |
dc.subject.keywordAuthor | in vivo xenograft model | - |
dc.subject.keywordAuthor | docking model | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CELLS | - |
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