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College of Natural Sciences(자연과학대학)Dept. of Chemistry(화학과)CH-Journal Papers(저널논문)

Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: Design, synthesis, and biological evaluation

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dc.contributor.authorChun, Kwangwooko
dc.contributor.authorPark, Song-Kyuko
dc.contributor.authorKim, Hwan Mookko
dc.contributor.authorChoi, Yongseokko
dc.contributor.authorKim, Myung-Hwako
dc.contributor.authorPark, Chun-Hoko
dc.contributor.authorJoe, Bo-Youngko
dc.contributor.authorChun, Tae Gyuko
dc.contributor.authorChoi, Hyun-Mooko
dc.contributor.authorLee, Hee Yoonko
dc.contributor.authorHong, Sung Heeko
dc.contributor.authorKim, Myung Sookko
dc.contributor.authorNam, Ky-Youbko
dc.contributor.authorHan, Gyoonheeko
dc.date.accessioned2013-03-07T07:43:23Z-
dc.date.available2013-03-07T07:43:23Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2008-01-
dc.identifier.citationBIOORGANIC MEDICINAL CHEMISTRY, v.16, no.1, pp.530 - 535-
dc.identifier.issn0968-0896-
dc.identifier.urihttp://hdl.handle.net/10203/89725-
dc.description.abstractA series of coumarin types MMP inhibitors were designed based on gelastatin hydroxamates (1) and evaluated for TACE, cellular TNF-alpha, and NO inhibitory activities. Among them, compounds 9b had potent inhibitory activities in enzymatic and cellular assays and good selectivity to MMP-2 and MMP-9. Further investigation of 9b will be carried out for its efficacy in RA animal model system. (c) 2007 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectNECROSIS-FACTOR-ALPHA-
dc.subjectCATALYTIC DOMAIN-
dc.subjectMETALLOPROTEINASE-
dc.subjectDISINTEGRIN-
dc.titleChromen-based TNF-alpha converting enzyme (TACE) inhibitors: Design, synthesis, and biological evaluation-
dc.typeArticle-
dc.identifier.wosid000253345400054-
dc.identifier.scopusid2-s2.0-38049028622-
dc.type.rimsART-
dc.citation.volume16-
dc.citation.issue1-
dc.citation.beginningpage530-
dc.citation.endingpage535-
dc.citation.publicationnameBIOORGANIC MEDICINAL CHEMISTRY-
dc.identifier.doi10.1016/j.bmc.2007.09.014-
dc.contributor.localauthorLee, Hee Yoon-
dc.contributor.nonIdAuthorChun, Kwangwoo-
dc.contributor.nonIdAuthorPark, Song-Kyu-
dc.contributor.nonIdAuthorKim, Hwan Mook-
dc.contributor.nonIdAuthorChoi, Yongseok-
dc.contributor.nonIdAuthorKim, Myung-Hwa-
dc.contributor.nonIdAuthorPark, Chun-Ho-
dc.contributor.nonIdAuthorJoe, Bo-Young-
dc.contributor.nonIdAuthorChun, Tae Gyu-
dc.contributor.nonIdAuthorChoi, Hyun-Moo-
dc.contributor.nonIdAuthorHong, Sung Hee-
dc.contributor.nonIdAuthorKim, Myung Sook-
dc.contributor.nonIdAuthorNam, Ky-Youb-
dc.contributor.nonIdAuthorHan, Gyoonhee-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorTNF-alpha converting enzyme (TACE)-
dc.subject.keywordAuthormetalloproteinase-2 (MMP-2)-
dc.subject.keywordAuthormetalloproteinase-9 (MMP-9)-
dc.subject.keywordAuthorrheumatoid arthritis (RA)-
dc.subject.keywordAuthorgelastatin hydroxamates-
dc.subject.keywordAuthorcoumarin derivatives-
dc.subject.keywordPlusNECROSIS-FACTOR-ALPHA-
dc.subject.keywordPlusCATALYTIC DOMAIN-
dc.subject.keywordPlusMETALLOPROTEINASE-
dc.subject.keywordPlusDISINTEGRIN-
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