DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, JR | ko |
dc.contributor.author | Cho, Kwang-Hyun | ko |
dc.date.accessioned | 2013-03-07T07:24:44Z | - |
dc.date.available | 2013-03-07T07:24:44Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-12 | - |
dc.identifier.citation | COMPUTATIONAL BIOLOGY AND CHEMISTRY, v.30, pp.438 - 444 | - |
dc.identifier.issn | 1476-9271 | - |
dc.identifier.uri | http://hdl.handle.net/10203/89694 | - |
dc.description.abstract | E. coli has two-component systems composed of histidine kinase proteins and response regulator proteins. For a given extracellular stimulus, a histidine kinase senses the stimulus, autophosphorylates and then passes the phosphates to the cognate response regulators. The histidine kinase in an orthodox two-component system has only one histidine domain where the autophosphorylation occurs, but a histidine kinase in some unusual two-component systems (unorthodox two-component systems) has two histidine domains and one aspartate domain. So, the unorthodox two-component systems have more complex phosphorelay mechanisms than orthodox two-component systems. In general, the two-component systems are required to promptly respond to external stimuli for survival of E. coli. In this respect, the complex multi-step phosphorelay mechanism seems to be disadvantageous, but there are several unorthodox two-component systems in E. coli. In this paper, we investigate the reason why such unorthodox two-component systems are present in E. coli. For this purpose, we have developed simplified mathematical models of both orthodox and unorthodox two-component systems and analyzed their dynamical characteristics through extensive computer simulations. We have finally revealed that the unorthodox two-component systems realize ultrasensitive responses to external stimuli and also more robust responses to noises than the orthodox two-component systems. (c) 2006 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | SIGNAL-TRANSDUCTION SYSTEM | - |
dc.subject | TORR RESPONSE REGULATOR | - |
dc.subject | ESCHERICHIA-COLI | - |
dc.subject | SENSOR | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | SENSITIVITY | - |
dc.subject | BVGAS | - |
dc.subject | EVGAS | - |
dc.subject | BARA | - |
dc.title | The multi-step phosphorelay mechanism of unorthodox two-component systems in E. coli realizes ultrasensitivity to stimuli while maintaining robustness to noises | - |
dc.type | Article | - |
dc.identifier.wosid | 000243091500006 | - |
dc.identifier.scopusid | 2-s2.0-33751233848 | - |
dc.type.rims | ART | - |
dc.citation.volume | 30 | - |
dc.citation.beginningpage | 438 | - |
dc.citation.endingpage | 444 | - |
dc.citation.publicationname | COMPUTATIONAL BIOLOGY AND CHEMISTRY | - |
dc.identifier.doi | 10.1016/j.compbiolchem.2006.09.004 | - |
dc.contributor.localauthor | Cho, Kwang-Hyun | - |
dc.contributor.nonIdAuthor | Kim, JR | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | two-component systems | - |
dc.subject.keywordAuthor | unorthodox two-component systems | - |
dc.subject.keywordAuthor | phosphorelay | - |
dc.subject.keywordAuthor | ultrasensitivity | - |
dc.subject.keywordAuthor | robustness | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION SYSTEM | - |
dc.subject.keywordPlus | TORR RESPONSE REGULATOR | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | SENSOR | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | BVGAS | - |
dc.subject.keywordPlus | EVGAS | - |
dc.subject.keywordPlus | BARA | - |
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