DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyoung | ko |
dc.contributor.author | Lee, Sue-Hyun | ko |
dc.contributor.author | Han, Jin-Hee | ko |
dc.contributor.author | Lee, Jin-A | ko |
dc.contributor.author | Chang, Deok-Jin | ko |
dc.contributor.author | Lee, Yong-Seok | ko |
dc.contributor.author | Kaang, Bong-Kiun | ko |
dc.contributor.author | Cheang, Ye-Hwang | ko |
dc.date.accessioned | 2013-03-07T07:19:47Z | - |
dc.date.available | 2013-03-07T07:19:47Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-03 | - |
dc.identifier.citation | NEURON, v.49, no.5, pp.707 - 718 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10203/89688 | - |
dc.description.abstract | In Aplysia, long-term synaptic plasticity is induced by serotonin (5-HT) or neural activity and requires gene expression. Here, we demonstrate that ApLLP, a novel nucleolus protein, is critically involved in both long-term facilitation (LTF) and behavioral sensitization. Membrane depolarization induced ApLLP expression, which activated ApC/EBP expression through a direct binding to CRE. LTF was produced by a single pulse of 5-HT 30 min after the membrane depolarization. This LTF was blocked when either ApLLP or ApC/EBP were blocked by specific antibodies. In contrast, ApLLP overexpression induced LTF in response to a single 5-HT treatment. Simultaneously, a siphon noxious stimulus (SNS) to intact Aplysia induced ApLLP and ApC/EBP expression, and single tail shock 30 min after SNS transformed short-term sensitization to long-term sensitization of siphon withdrawal reflex. These results suggest that ApLLP is an activity-dependent transcriptional activator that switches short-term facilitation to long-term facilitation. | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.title | A nucleolar protein ApLLP induces ApC/EBP expression required for long-term synaptic facilitation in Aplysia neurons | - |
dc.type | Article | - |
dc.identifier.wosid | 000236070600012 | - |
dc.identifier.scopusid | 2-s2.0-33344471385 | - |
dc.type.rims | ART | - |
dc.citation.volume | 49 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 707 | - |
dc.citation.endingpage | 718 | - |
dc.citation.publicationname | NEURON | - |
dc.identifier.doi | 10.1016/j.neuron.2006.01.035 | - |
dc.contributor.localauthor | Lee, Sue-Hyun | - |
dc.contributor.localauthor | Han, Jin-Hee | - |
dc.contributor.nonIdAuthor | Kim, Hyoung | - |
dc.contributor.nonIdAuthor | Lee, Jin-A | - |
dc.contributor.nonIdAuthor | Chang, Deok-Jin | - |
dc.contributor.nonIdAuthor | Lee, Yong-Seok | - |
dc.contributor.nonIdAuthor | Kaang, Bong-Kiun | - |
dc.contributor.nonIdAuthor | Cheang, Ye-Hwang | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | EARLY GENE ZIF268 | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | CELL-CULTURE | - |
dc.subject.keywordPlus | SEROTONERGIC MODULATION | - |
dc.subject.keywordPlus | INTERSTIMULUS-INTERVAL | - |
dc.subject.keywordPlus | SENSORIMOTOR SYNAPSES | - |
dc.subject.keywordPlus | WITHDRAWAL REFLEX | - |
dc.subject.keywordPlus | NERVE INJURY | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
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