DC Field | Value | Language |
---|---|---|
dc.contributor.author | Smith, Adam C. | ko |
dc.contributor.author | Heo, Won Do | ko |
dc.contributor.author | Braun, Virginie | ko |
dc.contributor.author | Jiang, Xiuju | ko |
dc.contributor.author | Macrae, Chloe | ko |
dc.contributor.author | Casanova, James E. | ko |
dc.contributor.author | Scidmore, Marci A. | ko |
dc.contributor.author | Grinstein, Sergio | ko |
dc.contributor.author | Meyer, Tobias | ko |
dc.contributor.author | Brumell, John H. | ko |
dc.date.accessioned | 2013-03-07T01:18:11Z | - |
dc.date.available | 2013-03-07T01:18:11Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-01 | - |
dc.identifier.citation | JOURNAL OF CELL BIOLOGY, v.176, no.3, pp.263 - 268 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.uri | http://hdl.handle.net/10203/89054 | - |
dc.description.abstract | Members of the Rab guanosine triphosphatase ( GTPase) family are key regulators of membrane traffic. Here we examined the association of 48 Rabs with model phagosomes containing a non-invasive mutant of Salmonella enterica serovar Typhimurium ( S. Typhimurium). This mutant traffics to lysosomes and allowed us to determine which Rabs localize to a maturing phagosome. In total, 18 Rabs associated with maturing phagosomes, each with its own kinetics of association. Dominant-negative mutants of Rab23 and 35 inhibited phagosome- lysosome fusion. A large number of Rab GTPases localized to wild-type Salmonella- containing vacuoles (SCVs), which do not fuse with lysosomes. However, some Rabs (8B, 13, 23, 32, and 35) were excluded from wild-type SCVs whereas others (5A, 5B, 5C, 7A, 11A, and 11B) were enriched on this compartment. Our studies demonstrate that a complex network of Rab GTPases controls endocytic progression to lysosomes and that this is modulated by S. Typhimurium to allow its intracellular growth. | - |
dc.language | English | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.title | A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium | - |
dc.type | Article | - |
dc.identifier.wosid | 000243997700003 | - |
dc.identifier.scopusid | 2-s2.0-33846576162 | - |
dc.type.rims | ART | - |
dc.citation.volume | 176 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 263 | - |
dc.citation.endingpage | 268 | - |
dc.citation.publicationname | JOURNAL OF CELL BIOLOGY | - |
dc.identifier.doi | 10.1083/jcb.200611056 | - |
dc.contributor.localauthor | Heo, Won Do | - |
dc.contributor.nonIdAuthor | Smith, Adam C. | - |
dc.contributor.nonIdAuthor | Braun, Virginie | - |
dc.contributor.nonIdAuthor | Jiang, Xiuju | - |
dc.contributor.nonIdAuthor | Macrae, Chloe | - |
dc.contributor.nonIdAuthor | Casanova, James E. | - |
dc.contributor.nonIdAuthor | Scidmore, Marci A. | - |
dc.contributor.nonIdAuthor | Grinstein, Sergio | - |
dc.contributor.nonIdAuthor | Meyer, Tobias | - |
dc.contributor.nonIdAuthor | Brumell, John H. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TRANS-GOLGI NETWORK | - |
dc.subject.keywordPlus | CONTAINING VACUOLES | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | LATE ENDOSOMES | - |
dc.subject.keywordPlus | ENDOCYTIC PATHWAY | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | LYSOSOMES | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | BIOGENESIS | - |
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