Impaired long-term memory and long-term potentiation in N-type Ca2+ channel-deficient mice

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dc.contributor.authorJeon, Daejongko
dc.contributor.authorKim, Cko
dc.contributor.authorYang, YMko
dc.contributor.authorRhim, Hko
dc.contributor.authorYim, Eko
dc.contributor.authorOh, Uko
dc.contributor.authorShin, HSko
dc.date.accessioned2013-03-06T23:40:56Z-
dc.date.available2013-03-06T23:40:56Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2007-06-
dc.identifier.citationGENES BRAIN AND BEHAVIOR, v.6, pp.375 - 388-
dc.identifier.issn1601-1848-
dc.identifier.urihttp://hdl.handle.net/10203/88847-
dc.description.abstractVoltage-dependent N-type Ca2+ channels, along with the P/Q-type, have a crucial role in controlling the release of neurotransmitters or neuromodulators at presynaptic terminals. However, their role in hippocampus-dependent learning and memory has never been examined. Here, we investigated hippocampus-dependent learning and memory and synaptic plasticity at hippocampal CA3-CA1 synapses in mice deficient for the alpha(1B) subunit of N-type Ca2+ channels. The mutant mice exhibited impaired learning and memory in the Morris water maze and the social transmission of food preference tasks. In particular, long-term memory was impaired in the mutant mice. Interestingly, among activity-dependent long-lasting synaptic changes, theta burst- or 200-Hz-stimulation-induced long-term potentiation (LTP) was decreased in the mutant, compared with the wild-type mice. This type of LTP is known to require brain-derived neurotrophic factor (BDNF). It was found that both BDNF-induced potentiation of field excitatory postsynaptic potentials and facilitation of the frequency of miniature excitatory postsynaptic currents (mEPSCs) were reduced in the mutant. Taken together, these results demonstrate that N-type Ca2+ channels are required for hippocampus-dependent learning and memory, and certain forms of LTP.-
dc.languageEnglish-
dc.publisherBLACKWELL PUBLISHING-
dc.subjectHIPPOCAMPAL EXCITATORY SYNAPSES-
dc.subjectDEPENDENT CALCIUM-CHANNELS-
dc.subjectNEUROTROPHIC FACTOR-
dc.subjectNEUROTRANSMITTER RELEASE-
dc.subjectSYNAPTIC-TRANSMISSION-
dc.subjectBDNF-
dc.subjectMODULATION-
dc.subjectNEURONS-
dc.subjectPLASTICITY-
dc.subjectENHANCEMENT-
dc.titleImpaired long-term memory and long-term potentiation in N-type Ca2+ channel-deficient mice-
dc.typeArticle-
dc.identifier.wosid000246684000009-
dc.identifier.scopusid2-s2.0-34249020422-
dc.type.rimsART-
dc.citation.volume6-
dc.citation.beginningpage375-
dc.citation.endingpage388-
dc.citation.publicationnameGENES BRAIN AND BEHAVIOR-
dc.identifier.doi10.1111/j.1601-183X.2006.00267.x-
dc.contributor.localauthorJeon, Daejong-
dc.contributor.nonIdAuthorKim, C-
dc.contributor.nonIdAuthorYang, YM-
dc.contributor.nonIdAuthorRhim, H-
dc.contributor.nonIdAuthorYim, E-
dc.contributor.nonIdAuthorOh, U-
dc.contributor.nonIdAuthorShin, HS-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorBDNF-
dc.subject.keywordAuthorCa(v)2.2 Ca2+-channel-
dc.subject.keywordAuthorhippocampus-
dc.subject.keywordAuthorlearning and memory-
dc.subject.keywordAuthorLTP-
dc.subject.keywordPlusHIPPOCAMPAL EXCITATORY SYNAPSES-
dc.subject.keywordPlusDEPENDENT CALCIUM-CHANNELS-
dc.subject.keywordPlusNEUROTROPHIC FACTOR-
dc.subject.keywordPlusNEUROTRANSMITTER RELEASE-
dc.subject.keywordPlusSYNAPTIC-TRANSMISSION-
dc.subject.keywordPlusBDNF-
dc.subject.keywordPlusMODULATION-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusPLASTICITY-
dc.subject.keywordPlusENHANCEMENT-
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