Dynamics of intestinal propulsion

Abstract

A biomechanical model and mathematical formulation of the problem of propulsion of a solid non-deformable pellet by an isolated segment of the gut are presented. The organ is modeled as a soft orthotropic cylindrical biological shell. Its wall is reinforced by transversely isotropic muscle fibers of orthogonal type of weaving embedded in a connective tissue stroma. The mechanical properties of the wall are assumed to be nonlinear, deformations are finite. The longitudinal smooth muscle syncitium possesses anisotropic and the circular muscle syncytium has anisotropic electrical properties. Their electromechanical activity is under control of a pacemaker, which is represented by interstitial cells of Cajal. The model describes the dynamics of the generation and propagation of mechanical waves of contraction-relaxation along the surface of the bioshell and propulsion of the pellet. The governing system of equations was solved numerically. The combined finite-difference and finite-element method was used. The results demonstrate that pendular movements alone provide an aboral transit, without mixing though, of the bolus. Non-propagating segmental contractions show small amplitude librations of the pellet without its visible propulsion. Only the coordinated activity of both smooth muscle layers in a form of the peristaltic reflex provides physiologically significant simultaneous propulsion and mixing of the intraluminal content (pellet). (c) 2007 Elsevier Ltd. All rights reserved.