Enantioselective conjugate radical addition to alpha '-hydroxy enones

Abstract

Enantioselective conjugate radical addition to alpha '-hydroxy alpha,beta-unsaturated ketones, compounds containing bidentate donors, has been investigated. It has been found that radical additions to alpha '-hydroxy alpha,beta-unsaturated ketones in the presence of Mg(NTf2)(2) and bisoxazoline ligand 5a proceeded cleanly, yielding the addition products in high chemical yields and good enantiomeric excesses.