Self-aggregates of oligoarginine-conjugated poly(amino acid) derivatives as a carrier for intracellular drug delivery

Cited 9 time in webofscience Cited 0 time in scopus
  • Hit : 366
  • Download : 0
N omega-2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl (N omega-Pbf)-protected oligoarginine was directly conjugated to poly(amino acid) derivatives modified with a long alkyl chain. The final concentration of conjugated peptides was easily controlled by the feed ratio of oligoarginine to polymer backbone and a final soluble polymeric system was obtained by the deprotection of N omega-Pbf groups. The polymeric conjugates formed stable self-aggregates of size range of 8-40 nm in aqueous solution and effectively internalized into HeLa cells by adsorptive endocytosis.
Publisher
SPRINGER
Issue Date
2005-07
Language
English
Article Type
Article
Keywords

ARGININE-RICH PEPTIDES; CELLULAR UPTAKE; MEMBRANE; CELLS; WATER

Citation

BIOTECHNOLOGY LETTERS, v.27, no.14, pp.977 - 982

ISSN
0141-5492
DOI
10.1007/s10529-005-7838-4
URI
http://hdl.handle.net/10203/87107
Appears in Collection
BS-Journal Papers(저널논문)CBE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 9 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0