Overexpression of Shinorhizobium meliloti hemoprotein in Streptomyces lividans to enhance secondary metabolite production

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dc.contributor.authorKim, Yoon Jungko
dc.contributor.authorSa, Soon Okko
dc.contributor.authorChang, YongKeunko
dc.contributor.authorHong, Soon-Kwangko
dc.contributor.authorHong, Young-Sooko
dc.date.accessioned2013-03-06T11:37:37Z-
dc.date.available2013-03-06T11:37:37Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2007-12-
dc.identifier.citationJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.17, no.12, pp.2066 - 2070-
dc.identifier.issn1017-7825-
dc.identifier.urihttp://hdl.handle.net/10203/86863-
dc.description.abstractIt was found that Shinorhizobium meliloti hemoprotein (SM) was more effective than Vitreoscilla hemoglobin (Vhb) in promoting secondary metabolites production when overexpressed in Streptomyces lividans TK24. The transformant with sm (sm-transformant) produced 2.7-times and 3-times larger amounts of actinorhodin than the vhb-transformant in solid culture and flask culture, respectively. In both solid and flask cultures, a larger amount of undecylprodigiocin was produced by the sm-transformant. It is considered that the overexpression of SM especially has activated the pentose phosphate pathway through oxidative stress, as evidenced by an increased NADPH production observed, and that it has promoted secondary metabolites biosynthesis.-
dc.languageEnglish-
dc.publisherKOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY-
dc.subjectVITREOSCILLA HEMOGLOBIN GENE-
dc.subjectRECOMBINANT ESCHERICHIA-COLI-
dc.subjectENTEROBACTER-AEROGENES-
dc.subjectBACTERIAL HEMOGLOBIN-
dc.subjectOXIDATIVE STRESS-
dc.subjectFLAVOHEMOGLOBIN GENE-
dc.subjectNUCLEOTIDE-SEQUENCE-
dc.subjectENERGY-METABOLISM-
dc.subjectCELL-GROWTH-
dc.subjectHMP GENE-
dc.titleOverexpression of Shinorhizobium meliloti hemoprotein in Streptomyces lividans to enhance secondary metabolite production-
dc.typeArticle-
dc.identifier.wosid000252255400022-
dc.identifier.scopusid2-s2.0-38149051178-
dc.type.rimsART-
dc.citation.volume17-
dc.citation.issue12-
dc.citation.beginningpage2066-
dc.citation.endingpage2070-
dc.citation.publicationnameJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY-
dc.contributor.localauthorChang, YongKeun-
dc.contributor.nonIdAuthorKim, Yoon Jung-
dc.contributor.nonIdAuthorSa, Soon Ok-
dc.contributor.nonIdAuthorHong, Soon-Kwang-
dc.contributor.nonIdAuthorHong, Young-Soo-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorbacterial hemoproteins-
dc.subject.keywordAuthorS. lividans-
dc.subject.keywordAuthorsecondary metabolites production-
dc.subject.keywordPlusVITREOSCILLA HEMOGLOBIN GENE-
dc.subject.keywordPlusRECOMBINANT ESCHERICHIA-COLI-
dc.subject.keywordPlusENTEROBACTER-AEROGENES-
dc.subject.keywordPlusBACTERIAL HEMOGLOBIN-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusFLAVOHEMOGLOBIN GENE-
dc.subject.keywordPlusNUCLEOTIDE-SEQUENCE-
dc.subject.keywordPlusENERGY-METABOLISM-
dc.subject.keywordPlusCELL-GROWTH-
dc.subject.keywordPlusHMP GENE-
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