DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, SH | ko |
dc.contributor.author | Ko, CH | ko |
dc.contributor.author | Lowrey, PL | ko |
dc.contributor.author | Buhr, ED | ko |
dc.contributor.author | Song, EJ | ko |
dc.contributor.author | Chang, SW | ko |
dc.contributor.author | Yoo, Ook-Joon | ko |
dc.contributor.author | Yamazaki, S | ko |
dc.contributor.author | Lee, C | ko |
dc.contributor.author | Takahashi, JS | ko |
dc.date.accessioned | 2013-03-06T07:37:31Z | - |
dc.date.available | 2013-03-06T07:37:31Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-02 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.102, no.7, pp.2608 - 2613 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/86300 | - |
dc.description.abstract | The mouse Period2 (mPer2) locus is an essential negative-feedback element of the mammalian circadian-clock mechanism. Recent work has shown that mPer2 circadian gene expression persists in both central and peripheral tissues. Here, we analyze the mouse mPer2 promoter and identify a circadian enhancer (E2) with a noncanonical 5'-CACGTT-3' E-box located 20 bp upstream of the mPer2 transcription start site. The E2 enhancer accounts for most circadian transcriptional drive of the mPer2 locus by CLOCK:BMAL1, is a major site of DNasel hypersensitivity in this region, and is constitutively bound by a transcriptional complex containing the CLOCK protein. Importantly, the E2 enhancer is sufficient to drive self-sustained circadian rhythms of luciferase activity in central and peripheral tissues from mPer2-E2::Luciferase transgenic mice with tissue-specific phase and period characteristics. Last, genetic analysis with mutations in Clock and Bmal1 shows that the E2 enhancer is a target of CLOCK and BMAL1 in vivo. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | CLOCK GENE | - |
dc.subject | INDIVIDUAL FIBROBLASTS | - |
dc.subject | REVEALS PERSISTENT | - |
dc.subject | EXPRESSION | - |
dc.subject | MPER1 | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | DROSOPHILA | - |
dc.subject | COMPONENT | - |
dc.subject | RHYTHMS | - |
dc.title | A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo | - |
dc.type | Article | - |
dc.identifier.wosid | 000227073100065 | - |
dc.identifier.scopusid | 2-s2.0-20044396172 | - |
dc.type.rims | ART | - |
dc.citation.volume | 102 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 2608 | - |
dc.citation.endingpage | 2613 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.0409763102 | - |
dc.contributor.localauthor | Yoo, Ook-Joon | - |
dc.contributor.nonIdAuthor | Yoo, SH | - |
dc.contributor.nonIdAuthor | Ko, CH | - |
dc.contributor.nonIdAuthor | Lowrey, PL | - |
dc.contributor.nonIdAuthor | Buhr, ED | - |
dc.contributor.nonIdAuthor | Song, EJ | - |
dc.contributor.nonIdAuthor | Chang, SW | - |
dc.contributor.nonIdAuthor | Yamazaki, S | - |
dc.contributor.nonIdAuthor | Lee, C | - |
dc.contributor.nonIdAuthor | Takahashi, JS | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Bmal1 gene | - |
dc.subject.keywordAuthor | circadian clock | - |
dc.subject.keywordAuthor | clock gene | - |
dc.subject.keywordAuthor | luciferase | - |
dc.subject.keywordAuthor | Period2 locus | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | CLOCK GENE | - |
dc.subject.keywordPlus | INDIVIDUAL FIBROBLASTS | - |
dc.subject.keywordPlus | REVEALS PERSISTENT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MPER1 | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | DROSOPHILA | - |
dc.subject.keywordPlus | COMPONENT | - |
dc.subject.keywordPlus | RHYTHMS | - |
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