DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seho | ko |
dc.contributor.author | Burette, Alain | ko |
dc.contributor.author | Chung, Hye Sun | ko |
dc.contributor.author | Kwon, Seok-Kyu | ko |
dc.contributor.author | Woo, Jooyeon | ko |
dc.contributor.author | Lee, Hyun Woo | ko |
dc.contributor.author | Kim, Karam | ko |
dc.contributor.author | Kim, Hyun | ko |
dc.contributor.author | Weinberg, Richard J. | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2013-03-06T07:36:35Z | - |
dc.date.available | 2013-03-06T07:36:35Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-10 | - |
dc.identifier.citation | NATURE NEUROSCIENCE, v.9, no.10, pp.1294 - 1301 | - |
dc.identifier.issn | 1097-6256 | - |
dc.identifier.uri | http://hdl.handle.net/10203/86299 | - |
dc.description.abstract | Synaptic cell adhesion molecules (CAMs) regulate synapse formation through their trans-synaptic and heterophilic adhesion. Here we show that postsynaptic netrin-G ligand (NGL)CAMs associate with netrin-G CAMs in an isoform-specific manner and, through their cytosolic tail, with the abundant postsynaptic scaffold postsynaptic density-95 (PSD-95). Overexpression of NGL-2 in cultured rat neurons increased the number of PSD-95-positive dendritic protrusions. NGL-2 located on heterologous cells or beads induced functional presynaptic differentiation in contacting neurites. Direct aggregation of NGL-2 on the surface membrane of dendrites induced the clustering of excitatory postsynaptic proteins. Competitive inhibition by soluble NGL-2 reduced the number of excitatory synapses. NGL-2 knockdown reduced excitatory, but not inhibitory, synapse numbers and currents. These results suggest that NGL regulates the formation of excitatory synapses. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CELL-ADHESION | - |
dc.subject | INHIBITORY SYNAPSES | - |
dc.subject | BETA-NEUREXINS | - |
dc.subject | NEUROLIGIN | - |
dc.subject | BINDING | - |
dc.subject | GENES | - |
dc.subject | PSD-95 | - |
dc.subject | AUTISM | - |
dc.subject | NETRIN-G1 | - |
dc.subject | EXPRESSION | - |
dc.title | NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation | - |
dc.type | Article | - |
dc.identifier.wosid | 000241493900023 | - |
dc.identifier.scopusid | 2-s2.0-33749026932 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.issue | 10 | - |
dc.citation.beginningpage | 1294 | - |
dc.citation.endingpage | 1301 | - |
dc.citation.publicationname | NATURE NEUROSCIENCE | - |
dc.identifier.doi | 10.1038/nn1763 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Kim, Seho | - |
dc.contributor.nonIdAuthor | Burette, Alain | - |
dc.contributor.nonIdAuthor | Chung, Hye Sun | - |
dc.contributor.nonIdAuthor | Kwon, Seok-Kyu | - |
dc.contributor.nonIdAuthor | Woo, Jooyeon | - |
dc.contributor.nonIdAuthor | Lee, Hyun Woo | - |
dc.contributor.nonIdAuthor | Kim, Karam | - |
dc.contributor.nonIdAuthor | Kim, Hyun | - |
dc.contributor.nonIdAuthor | Weinberg, Richard J. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CELL-ADHESION | - |
dc.subject.keywordPlus | INHIBITORY SYNAPSES | - |
dc.subject.keywordPlus | BETA-NEUREXINS | - |
dc.subject.keywordPlus | NEUROLIGIN | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | PSD-95 | - |
dc.subject.keywordPlus | AUTISM | - |
dc.subject.keywordPlus | NETRIN-G1 | - |
dc.subject.keywordPlus | EXPRESSION | - |
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