DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chern, JJ | ko |
dc.contributor.author | Choi, Kwang-Wook | ko |
dc.date.accessioned | 2013-03-06T05:53:47Z | - |
dc.date.available | 2013-03-06T05:53:47Z | - |
dc.date.created | 2012-08-28 | - |
dc.date.created | 2012-08-28 | - |
dc.date.issued | 2002-09 | - |
dc.identifier.citation | DEVELOPMENT, v.129, no.17, pp.4005 - 4013 | - |
dc.identifier.issn | 0950-1991 | - |
dc.identifier.uri | http://hdl.handle.net/10203/86021 | - |
dc.description.abstract | Notch (N) activation at the dorsoventral (DV) boundary of the Drosophila eye is required for early eye primordium growth. Despite the apparent DV mirror symmetry, some mutations cause a preferential loss of the ventral domain, suggesting that the growth of individual domains is asymmetrically regulated. We show that the Lobe (L) gene is required non-autonomously for ventral growth but not dorsal growth, and that it mediates the proliferative effect of midline N signaling in a ventral-specific manner. L encodes a novel protein with a conserved domain. Loss of L suppresses the overproliferation phenotype of constitutive N activation in the ventral, but not in the dorsal eye, and gain of L rescues ventral tissue loss in N mutant background. Furthermore, L is necessary and sufficient for the ventral expression of a N ligand, Serrate (Ser), which affects ventral growth. Our data suggest that the control of ventral Ser expression by L represents a molecular mechanism that governs asymmetrical eye growth. | - |
dc.language | English | - |
dc.publisher | COMPANY OF BIOLOGISTS LTD | - |
dc.subject | WING IMAGINAL DISC | - |
dc.subject | MORPHOGENETIC FURROW | - |
dc.subject | CELL-PROLIFERATION | - |
dc.subject | FRINGE | - |
dc.subject | SERRATE | - |
dc.subject | DELTA | - |
dc.subject | POLARITY | - |
dc.subject | ACTIVATION | - |
dc.subject | LIGAND | - |
dc.subject | BOUNDARY | - |
dc.title | Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc | - |
dc.type | Article | - |
dc.identifier.wosid | 000177958800005 | - |
dc.identifier.scopusid | 2-s2.0-0036713098 | - |
dc.type.rims | ART | - |
dc.citation.volume | 129 | - |
dc.citation.issue | 17 | - |
dc.citation.beginningpage | 4005 | - |
dc.citation.endingpage | 4013 | - |
dc.citation.publicationname | DEVELOPMENT | - |
dc.contributor.localauthor | Choi, Kwang-Wook | - |
dc.contributor.nonIdAuthor | Chern, JJ | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Notch signaling | - |
dc.subject.keywordAuthor | dorsoventral patterning | - |
dc.subject.keywordAuthor | growth control | - |
dc.subject.keywordAuthor | imaginal disc development | - |
dc.subject.keywordAuthor | Drosophila | - |
dc.subject.keywordPlus | WING IMAGINAL DISC | - |
dc.subject.keywordPlus | MORPHOGENETIC FURROW | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | FRINGE | - |
dc.subject.keywordPlus | SERRATE | - |
dc.subject.keywordPlus | DELTA | - |
dc.subject.keywordPlus | POLARITY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | BOUNDARY | - |
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