DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mook-Jung, I | ko |
dc.contributor.author | Kim, H | ko |
dc.contributor.author | Fan, WZ | ko |
dc.contributor.author | Tezuka, Y | ko |
dc.contributor.author | Kadota, S | ko |
dc.contributor.author | Nishijo, H | ko |
dc.contributor.author | Jung, MW | ko |
dc.date.accessioned | 2013-03-06T05:18:11Z | - |
dc.date.available | 2013-03-06T05:18:11Z | - |
dc.date.created | 2013-02-20 | - |
dc.date.created | 2013-02-20 | - |
dc.date.issued | 2002-08 | - |
dc.identifier.citation | BIOLOGICAL PHARMACEUTICAL BULLETIN, v.25, no.8, pp.1101 - 1104 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | http://hdl.handle.net/10203/85927 | - |
dc.description.abstract | We tested the constituents of two Rhodiola plants, Rhodiola sacra S. H. Fu and R. sachalinensis A. Box, and an Oriental crude drug, Tokaku-joki-to, for their neuroprotective effects. Of the 58 compounds tested, six had considerable protective effects against beta-amyloid-induced death of B103 neuronal cells in vitro. These six compounds also showed protective effects against staurosporine-induced cell death, and two of the six compounds protected neurons from H2O2-induced cell death. These results suggest that some of the tested compounds protect neurons from beta-amyloid toxicity based on antiapoptotic and antioxidative activity. | - |
dc.language | English | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.subject | PROLYL ENDOPEPTIDASE INHIBITORS | - |
dc.subject | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject | UNDERGROUND PART | - |
dc.subject | CELLS | - |
dc.subject | ESTROGEN | - |
dc.title | Neuroprotective effects of constituents of the oriental crude drugs, Rhodiola sacra, R-sachalinensis and Tokaku-joki-to, against beta-amyloid toxicity, oxidative stress and apoptosis | - |
dc.type | Article | - |
dc.identifier.wosid | 000177198000031 | - |
dc.identifier.scopusid | 2-s2.0-0036692141 | - |
dc.type.rims | ART | - |
dc.citation.volume | 25 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 1101 | - |
dc.citation.endingpage | 1104 | - |
dc.citation.publicationname | BIOLOGICAL PHARMACEUTICAL BULLETIN | - |
dc.identifier.doi | 10.1248/bpb.25.1101 | - |
dc.contributor.localauthor | Jung, MW | - |
dc.contributor.nonIdAuthor | Mook-Jung, I | - |
dc.contributor.nonIdAuthor | Kim, H | - |
dc.contributor.nonIdAuthor | Fan, WZ | - |
dc.contributor.nonIdAuthor | Tezuka, Y | - |
dc.contributor.nonIdAuthor | Kadota, S | - |
dc.contributor.nonIdAuthor | Nishijo, H | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | beta-amyloid | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | natural medicine | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | B103 cell | - |
dc.subject.keywordPlus | PROLYL ENDOPEPTIDASE INHIBITORS | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | UNDERGROUND PART | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ESTROGEN | - |
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