DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, SC | ko |
dc.contributor.author | Choi, Kwang-Wook | ko |
dc.date.accessioned | 2013-03-06T05:06:49Z | - |
dc.date.available | 2013-03-06T05:06:49Z | - |
dc.date.created | 2012-08-28 | - |
dc.date.created | 2012-08-28 | - |
dc.date.issued | 2003-09 | - |
dc.identifier.citation | DEVELOPMENT, v.130, no.18, pp.4363 - 4372 | - |
dc.identifier.issn | 0950-1991 | - |
dc.identifier.uri | http://hdl.handle.net/10203/85898 | - |
dc.description.abstract | Apicobasal cell polarity is crucial for morphogenesis of photoreceptor rhabdomeres and adherens junctions (AJs) in the Drosophila eye. Crumbs (Crb) is specifically localized to the apical membrane of photoreceptors, providing a positional cue for the organization of rhabdomeres and AJs. We show that the Crb complex consisting of Crb, Stardust (Sdt) and Discs-lost (Dlt) colocalizes with another protein complex containing Par-6 and atypical protein kinase C (aPKC) in the rhabdomere stalk of photoreceptors. Loss of each component of the Crb complex causes age-dependent mislocalization. of Par-6 complex proteins, and ectopic expression of Crb 4363 intracellular domain is sufficient to recruit the Par-6 complex. We also show that the absence of Par-6 complex proteins results in severe mislocalization and loss of Crb complex. We further demonstrate that Dlt directly hinds to Par-6, providing a molecular basis for the mutual dependence of the two complexes. These results suggest that the interaction of Crb and Par-6 complexes is required for the organization and maintenance of apical membranes and AJs of photoreceptors. | - |
dc.language | English | - |
dc.publisher | COMPANY OF BIOLOGISTS LTD | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | EPITHELIAL TIGHT JUNCTION | - |
dc.subject | CELL-POLARITY | - |
dc.subject | RETINITIS-PIGMENTOSA | - |
dc.subject | ADHERENS JUNCTIONS | - |
dc.subject | ZONULA ADHERENS | - |
dc.subject | HUMAN HOMOLOG | - |
dc.subject | STARDUST | - |
dc.subject | BAZOOKA | - |
dc.subject | NEUROBLASTS | - |
dc.title | Interaction of Par-6 and Crumbs complexes is essential for photoreceptor morphogenesis in Drosophila | - |
dc.type | Article | - |
dc.identifier.wosid | 000187398800013 | - |
dc.identifier.scopusid | 2-s2.0-0141502071 | - |
dc.type.rims | ART | - |
dc.citation.volume | 130 | - |
dc.citation.issue | 18 | - |
dc.citation.beginningpage | 4363 | - |
dc.citation.endingpage | 4372 | - |
dc.citation.publicationname | DEVELOPMENT | - |
dc.identifier.doi | 10.1242/dev.00648 | - |
dc.contributor.localauthor | Choi, Kwang-Wook | - |
dc.contributor.nonIdAuthor | Nam, SC | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Drosophila | - |
dc.subject.keywordAuthor | Crumbs | - |
dc.subject.keywordAuthor | discs-lost | - |
dc.subject.keywordAuthor | Par-6 | - |
dc.subject.keywordAuthor | photoreceptor | - |
dc.subject.keywordAuthor | rhabdomere | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | EPITHELIAL TIGHT JUNCTION | - |
dc.subject.keywordPlus | CELL-POLARITY | - |
dc.subject.keywordPlus | RETINITIS-PIGMENTOSA | - |
dc.subject.keywordPlus | ADHERENS JUNCTIONS | - |
dc.subject.keywordPlus | ZONULA ADHERENS | - |
dc.subject.keywordPlus | HUMAN HOMOLOG | - |
dc.subject.keywordPlus | STARDUST | - |
dc.subject.keywordPlus | BAZOOKA | - |
dc.subject.keywordPlus | NEUROBLASTS | - |
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