DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Ahn, JM | ko |
dc.contributor.author | Kim, CH | ko |
dc.contributor.author | Choi, Y | ko |
dc.contributor.author | Ahn, YS | ko |
dc.contributor.author | Kim, H | ko |
dc.contributor.author | Kim, SJ | ko |
dc.contributor.author | Park, JH | ko |
dc.date.accessioned | 2013-03-06T04:11:01Z | - |
dc.date.available | 2013-03-06T04:11:01Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2001-07 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF CANCER, v.93, no.2, pp.262 - 268 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | http://hdl.handle.net/10203/85765 | - |
dc.description.abstract | We demonstrated the induction of cell death in a hepatoma cell line by IFN-gamma and its possible mechanism. Among the 2 hepatitis B virus (HBV)-associated hepatoma cell lines, SNU-354 and SNU-368, IFN-gamma induced cell death and increased caspase-3 activity in SNU-368 but not in SNU-354. IFP-gamma induced several changes in the mRNA expression level of apoptosis-regulating genes, e.g., increased expression of pas, caspase-1 and TNF-related apoptosis-inducing ligand (TRAIL). In particular, IFN-gamma potently increased the mRNA expression of TRAIL in both cell lines. However, it did not change the mRNA expression level of death-mediating TRAIL receptors, e.g,, DR4 and DR5, which were constitutively expressed in both cell lines. In contrast, the decoy receptor DcR1 was expressed in SNU-354 but not in SNU-368, and its expression level in SNU-354 was increased by IFN-gamma. Another decoy receptor, DcR2, was constitutively expressed in both cell lines; however, its expression level in SNU-368 was decreased by IFN-gamma, In addition, exogenous recombinant TRAIL reduced viability in SNU-368, but not in SNU-354, cells. From these findings, we speculated that TRAIL up-regulation and the subsequent TRAIL-mediated apoptosis serve as a mechanism of IFN-gamma -induced cell death in SNU-368. To confirm this hypothesis, we demonstrated that soluble DR4-Fc fusion protein, a TRAIL pathway inhibitor, inhibited IFN-gamma -induced cell death in SNU-368. Our results demonstrated that IFN-gamma acts as an inducer of cell death through TRAIL-mediated apoptosis. (C) 2001 Wiley-Liss, Inc. | - |
dc.language | English | - |
dc.publisher | WILEY-LISS | - |
dc.subject | TRAIL-INDUCED APOPTOSIS | - |
dc.subject | CYTOTOXIC LIGAND TRAIL | - |
dc.subject | INTERFERON-GAMMA | - |
dc.subject | FAS LIGAND | - |
dc.subject | TNF-ALPHA | - |
dc.subject | TUMORICIDAL ACTIVITY | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | UP-REGULATION | - |
dc.subject | CANCER-CELLS | - |
dc.subject | TUMOR-CELLS | - |
dc.title | IFN-gamma induces cell death in human hepatoma cells through a trail/death receptor-mediated apoptotic pathway | - |
dc.type | Article | - |
dc.identifier.wosid | 000169299200016 | - |
dc.identifier.scopusid | 2-s2.0-0035879751 | - |
dc.type.rims | ART | - |
dc.citation.volume | 93 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 262 | - |
dc.citation.endingpage | 268 | - |
dc.citation.publicationname | INTERNATIONAL JOURNAL OF CANCER | - |
dc.identifier.doi | 10.1002/ijc.1310 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Ahn, JM | - |
dc.contributor.nonIdAuthor | Kim, CH | - |
dc.contributor.nonIdAuthor | Choi, Y | - |
dc.contributor.nonIdAuthor | Ahn, YS | - |
dc.contributor.nonIdAuthor | Kim, H | - |
dc.contributor.nonIdAuthor | Kim, SJ | - |
dc.contributor.nonIdAuthor | Park, JH | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | IFN-gamma | - |
dc.subject.keywordAuthor | hepatoma | - |
dc.subject.keywordAuthor | TRAIL | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | death receptor | - |
dc.subject.keywordPlus | TRAIL-INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | CYTOTOXIC LIGAND TRAIL | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | FAS LIGAND | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | TUMORICIDAL ACTIVITY | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | TUMOR-CELLS | - |
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