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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

Inhibition of the helicase activity of HCVNTPase/helicase by 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5 -triphosphate (ribavirin-TP)

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dc.contributor.authorBorowski, Pko
dc.contributor.authorLang, Mko
dc.contributor.authorNiebuhr, Ako
dc.contributor.authorHaag, Ako
dc.contributor.authorSchmitz, Hko
dc.contributor.authorzur Wiesch, JSko
dc.contributor.authorChoe, Joonhoko
dc.contributor.authorSiwecka, MAko
dc.contributor.authorKulikowski, Tko
dc.date.accessioned2013-03-06T03:44:25Z-
dc.date.available2013-03-06T03:44:25Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2001-09-
dc.identifier.citationACTA BIOCHIMICA POLONICA, v.48, no.3, pp.739 - 744-
dc.identifier.issn0001-527X-
dc.identifier.urihttp://hdl.handle.net/10203/85716-
dc.description.abstractIn the presented study the ribavirin-TP - an established inhibitor of the NTPase activity of the superfamily NTPase/helicases II - was investigated as an inhibitor of the unwinding activity of the hepatitis C virus (HCV) NTPase/helicase. The kinetics of the reaction revealed that ribavirin-TP reduces the turnover number of the helicase reaction by a mechanism that does not correspond to that of the inhibition of the NTPase activity. Our results suggest that derivatives of ribavirin-TP with enhanced stability towards hydrolytic attack may be effective inhibitors of the enzyme.-
dc.languageEnglish-
dc.publisherACTA BIOCHIMICA POLONICA-
dc.subjectHEPATITIS-C VIRUS-
dc.subjectRNA HELICASE-
dc.subjectNS3 PROTEIN-
dc.subjectNUCLEOSIDE 5&apos-
dc.subject-TRIPHOSPHATES-
dc.subjectBINDING ACTIVITY-
dc.subjectDOMAIN-
dc.subjectNTPASE/HELICASE-
dc.titleInhibition of the helicase activity of HCVNTPase/helicase by 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5 -triphosphate (ribavirin-TP)-
dc.typeArticle-
dc.identifier.wosid000171292600016-
dc.identifier.scopusid2-s2.0-0035753788-
dc.type.rimsART-
dc.citation.volume48-
dc.citation.issue3-
dc.citation.beginningpage739-
dc.citation.endingpage744-
dc.citation.publicationnameACTA BIOCHIMICA POLONICA-
dc.contributor.localauthorChoe, Joonho-
dc.contributor.nonIdAuthorBorowski, P-
dc.contributor.nonIdAuthorLang, M-
dc.contributor.nonIdAuthorNiebuhr, A-
dc.contributor.nonIdAuthorHaag, A-
dc.contributor.nonIdAuthorSchmitz, H-
dc.contributor.nonIdAuthorzur Wiesch, JS-
dc.contributor.nonIdAuthorSiwecka, MA-
dc.contributor.nonIdAuthorKulikowski, T-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorHCV helicase-
dc.subject.keywordAuthorenzyme inhibition-
dc.subject.keywordAuthorribavirin-5 &apos-
dc.subject.keywordAuthor-triphosphate-
dc.subject.keywordPlusHEPATITIS-C VIRUS-
dc.subject.keywordPlusRNA HELICASE-
dc.subject.keywordPlusNS3 PROTEIN-
dc.subject.keywordPlusNUCLEOSIDE 5&apos-
dc.subject.keywordPlus-TRIPHOSPHATES-
dc.subject.keywordPlusBINDING ACTIVITY-
dc.subject.keywordPlusDOMAIN-
dc.subject.keywordPlusNTPASE/HELICASE-
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