DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, KM | ko |
dc.contributor.author | Kim, YS | ko |
dc.contributor.author | Jeong, TC | ko |
dc.contributor.author | Joe, Cheol O | ko |
dc.contributor.author | Shin, HJ | ko |
dc.contributor.author | Lee, YH | ko |
dc.contributor.author | Nam, KY | ko |
dc.contributor.author | Park, JD | ko |
dc.date.accessioned | 2013-03-06T03:41:08Z | - |
dc.date.available | 2013-03-06T03:41:08Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2001-03 | - |
dc.identifier.citation | PLANTA MEDICA, v.67, no.2, pp.122 - 126 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | http://hdl.handle.net/10203/85710 | - |
dc.description.abstract | The effects of an acidic polysaccharide isolated from the ethanol-insoluble and water-soluble fraction of Panax ginseng C. A. Meyer on immunomodulating activities were investigated. A high output nitric oxide synthase (iNOS) was shown in female BALB/c mice administered intraperitoneally with the acidic polysaccharide from ginseng. Newly synthesized iNOS protein was also observed in peritoneal macrophages cultured with interferon-gamma and the acidic polysaccharide. Spleen cells from acidic polysaccharide-treated mice did not proliferate in response to concanavalin A, but restored the responsiveness by the cotreatment of N-G-monomethyl-(L)-arginine (NMMA) with concanavalin A. The treatment of mice with aminoguanidine, a specific iNOS inhibitor, alleviated the acidic polysaccharide-induced suppression of antibody response to sheep red blood cells. Present results suggest that the immunomodulating activities of the acidic polysaccharide were mediated by the production of nitric oxide. | - |
dc.language | English | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.subject | SALMONELLA-TYPHIMURIUM | - |
dc.subject | ATTENUATED SALMONELLA | - |
dc.subject | MACROPHAGE | - |
dc.subject | IMMUNOSUPPRESSION | - |
dc.subject | CELL | - |
dc.subject | PATHWAY | - |
dc.subject | SUPPRESSION | - |
dc.subject | GINSAN | - |
dc.subject | STRAIN | - |
dc.title | Nitric oxide is involved in the immunomodulating activities of acidic polysaccharide from Panax ginseng | - |
dc.type | Article | - |
dc.identifier.wosid | 000167827400005 | - |
dc.identifier.scopusid | 2-s2.0-0035083855 | - |
dc.type.rims | ART | - |
dc.citation.volume | 67 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 122 | - |
dc.citation.endingpage | 126 | - |
dc.citation.publicationname | PLANTA MEDICA | - |
dc.identifier.doi | 10.1055/s-2001-11508 | - |
dc.contributor.localauthor | Joe, Cheol O | - |
dc.contributor.nonIdAuthor | Park, KM | - |
dc.contributor.nonIdAuthor | Kim, YS | - |
dc.contributor.nonIdAuthor | Jeong, TC | - |
dc.contributor.nonIdAuthor | Shin, HJ | - |
dc.contributor.nonIdAuthor | Lee, YH | - |
dc.contributor.nonIdAuthor | Nam, KY | - |
dc.contributor.nonIdAuthor | Park, JD | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | polysaccharide | - |
dc.subject.keywordAuthor | Panax ginseng | - |
dc.subject.keywordAuthor | Araliaceae | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordPlus | SALMONELLA-TYPHIMURIUM | - |
dc.subject.keywordPlus | ATTENUATED SALMONELLA | - |
dc.subject.keywordPlus | MACROPHAGE | - |
dc.subject.keywordPlus | IMMUNOSUPPRESSION | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | GINSAN | - |
dc.subject.keywordPlus | STRAIN | - |
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