DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Chunghun | ko |
dc.contributor.author | Seo, Taegun | ko |
dc.contributor.author | Jung, Jun | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.date.accessioned | 2013-03-06T03:03:20Z | - |
dc.date.available | 2013-03-06T03:03:20Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004-04 | - |
dc.identifier.citation | JOURNAL OF GENERAL VIROLOGY, v.85, pp.843 - 855 | - |
dc.identifier.issn | 0022-1317 | - |
dc.identifier.uri | http://hdl.handle.net/10203/85626 | - |
dc.description.abstract | Latency-associated nuclear antigen 1 (LANA1) of Kaposi's sarcoma-associated herpesvirus (KSHV) plays a pivotal role in the maintenance of the virus genome in latently infected cells. LANA1 links virus genomes to host chromosomes via a C-terminal DNA-binding domain which interacts with the sequences located in terminal repeats (TRs) of the virus genome and via an N-terminal chromosome-binding sequence which associates with the host chromosomes, respectively. Recent data suggest that LANA1 also actively participates in the replication of KSHV TR-containing plasmid in the transient DNA replication assay. In this report, it was found that C33A and COS-1, but not NIH/3T3, cell lines are permissive for the transient replication of KSHV TR-containing plasmid. Using several LANA1-deletion mutants, the minimum domain of LANA1 required for replication activity was also determined. In addition, the N terminus of LANA1 inhibited the transient replication systems of KSHV and Epstein-Barr virus (EBV) in transiently transfected 293 and 293T cells, but the C terminus of LANA1 specifically inhibited the transient replication system of KSHV in other cell lines. Consistent with previous reports, these data further emphasize the functional importance of the N terminus of LANA1 on replication from the KSHV latent origin of DNA replication. | - |
dc.language | English | - |
dc.publisher | SOC GENERAL MICROBIOLOGY | - |
dc.title | Identification of a virus trans-acting regulatory element on the latent DNA replication of Kaposis sarcoma-associated herpesvirus | - |
dc.type | Article | - |
dc.identifier.wosid | 000220628700009 | - |
dc.identifier.scopusid | 2-s2.0-1842843635 | - |
dc.type.rims | ART | - |
dc.citation.volume | 85 | - |
dc.citation.beginningpage | 843 | - |
dc.citation.endingpage | 855 | - |
dc.citation.publicationname | JOURNAL OF GENERAL VIROLOGY | - |
dc.identifier.doi | 10.1099/vir.0.19510-0 | - |
dc.contributor.localauthor | Lim, Chunghun | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Seo, Taegun | - |
dc.contributor.nonIdAuthor | Jung, Jun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | EPSTEIN-BARR-VIRUS | - |
dc.subject.keywordPlus | S-PHASE ENTRY | - |
dc.subject.keywordPlus | READING FRAME 50 | - |
dc.subject.keywordPlus | NUCLEAR ANTIGEN | - |
dc.subject.keywordPlus | TERMINAL REPEAT | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL ACTIVATION | - |
dc.subject.keywordPlus | CARBOXY-TERMINUS | - |
dc.subject.keywordPlus | RESPONSE ELEMENT | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
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