DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sunhong | ko |
dc.contributor.author | Lee, Jiwoon | ko |
dc.contributor.author | Park, Jeehye | ko |
dc.contributor.author | Chung, Jongkyeong | ko |
dc.date.accessioned | 2009-02-24T05:20:06Z | - |
dc.date.available | 2009-02-24T05:20:06Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2003-08 | - |
dc.identifier.citation | CANCER RESEARCH, v.63, no.16, pp.4792 - 4795 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://hdl.handle.net/10203/8552 | - |
dc.description.abstract | To identify novel regulators of Wnt signaling, we performed yeast two-hybrid analyses with Dvl-1 and identified BP75 as a candidate. Here, we demonstrated that BP75 directly interacts with Dvl-1 in mammalian cells and enhances TCF-dependent gene expression induced by Dvl-1. In support of these results, BP75 in cooperation with Dvl-1 was found to facilitate dephosphorylation at Tyr216 of glycogen synthase kinase-3beta and consequently inhibit its kinase activity. Furthermore, the nuclear translocation and formation of vesicular structures of beta-catenin were induced by BP75 and Dvl-1 in a synergistic manner. Collectively, these results provided us a novel mechanism in Wnt signaling where BP75 plays important regulatory roles between glycogen synthase kinase-3beta and Dvl. | - |
dc.description.sponsorship | This research was supported by a National Creative Research Initiatives grant from the Korean Ministry of Science and Technology/KOSEF. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Amer Assoc Cancer Research | - |
dc.subject | BETA-CATENIN | - |
dc.subject | KINASE-C | - |
dc.subject | AXIN | - |
dc.subject | PATHWAY | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | INHIBITION | - |
dc.subject | DROSOPHILA | - |
dc.subject | FAMILY | - |
dc.title | BP75, Bromodomain-containing Mr 75,000 Protein, Binds Dishevelled-1 and Enhances Wnt Signaling by Inactivating Glycogen Synthase Kinase-3ß | - |
dc.type | Article | - |
dc.identifier.wosid | 000184948400008 | - |
dc.identifier.scopusid | 2-s2.0-0041940132 | - |
dc.type.rims | ART | - |
dc.citation.volume | 63 | - |
dc.citation.issue | 16 | - |
dc.citation.beginningpage | 4792 | - |
dc.citation.endingpage | 4795 | - |
dc.citation.publicationname | CANCER RESEARCH | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Chung, Jongkyeong | - |
dc.contributor.nonIdAuthor | Kim, Sunhong | - |
dc.contributor.nonIdAuthor | Lee, Jiwoon | - |
dc.contributor.nonIdAuthor | Park, Jeehye | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | KINASE-C | - |
dc.subject.keywordPlus | AXIN | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | DROSOPHILA | - |
dc.subject.keywordPlus | FAMILY | - |
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