DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Daeyoup | ko |
dc.contributor.author | Hwang, SG | ko |
dc.contributor.author | Kim, J | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.date.accessioned | 2013-03-04T23:43:55Z | - |
dc.date.available | 2013-03-04T23:43:55Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2002-02 | - |
dc.identifier.citation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.277, no.8, pp.6483 - 6489 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/10203/84683 | - |
dc.description.abstract | p300/CREB-binding protein-associated factor (p/CAF), a transcriptional co-activator, interacts with co-activator p300/CBP and acidic transcription factors. p/CAF mediates transcriptional activation by acetylating nucleosomal histones and cellular factors. Previously we reported that CBP binds to human papillomavirus E2 and activates E2-dependent transcription (Lee, D., Lee, B., Kim, J., Kim, D. W., and Choe, J. (2000) J. Biol. Chem. 275, 7045-7051). Here we show that p/CAF binds to the human papillomavirus E2 protein in vivo and in vitro and activates E2-dependent transcription. CBP along with p/CAF synergistically activates E2-dependent transcription. In addition, the histone acetylase activity of p/CAF is required for efficient activation of E2 transcriptional activity. These results suggest that p/CAF is a transcriptional co-activator of the human papillomavirus E2 protein. | - |
dc.language | English | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.subject | NUCLEAR RECEPTOR COACTIVATOR | - |
dc.subject | HISTONE ACETYLASE PCAF | - |
dc.subject | TERMINAL DOMAIN | - |
dc.subject | ACETYLTRANSFERASE | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | ACTIVATION | - |
dc.subject | COMPLEX | - |
dc.subject | P300 | - |
dc.subject | CBP | - |
dc.subject | DNA | - |
dc.title | Functional interaction between p/CAF and human papillomavirus E2 protein | - |
dc.type | Article | - |
dc.identifier.wosid | 000173989200104 | - |
dc.identifier.scopusid | 2-s2.0-0037155270 | - |
dc.type.rims | ART | - |
dc.citation.volume | 277 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 6483 | - |
dc.citation.endingpage | 6489 | - |
dc.citation.publicationname | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.contributor.localauthor | Lee, Daeyoup | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Hwang, SG | - |
dc.contributor.nonIdAuthor | Kim, J | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NUCLEAR RECEPTOR COACTIVATOR | - |
dc.subject.keywordPlus | HISTONE ACETYLASE PCAF | - |
dc.subject.keywordPlus | TERMINAL DOMAIN | - |
dc.subject.keywordPlus | ACETYLTRANSFERASE | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | P300 | - |
dc.subject.keywordPlus | CBP | - |
dc.subject.keywordPlus | DNA | - |
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