DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, YoonSung | ko |
dc.contributor.author | Kim, JW | ko |
dc.contributor.author | Han, SH | ko |
dc.contributor.author | Chang, IS | ko |
dc.date.accessioned | 2013-03-04T20:54:01Z | - |
dc.date.available | 2013-03-04T20:54:01Z | - |
dc.date.created | 2012-03-19 | - |
dc.date.created | 2012-03-19 | - |
dc.date.issued | 2003-03 | - |
dc.identifier.citation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.9, pp.153 - 158 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | http://hdl.handle.net/10203/84104 | - |
dc.description.abstract | An adhesive patch-type delivery system is suggested for sustained dermal application of vitamin A. Poly(acrylate-co-vinylacetate) was used as a pressure-sensitive adhesive. In vivo skin permeation of vitamin A from the patch was studied and compared with that of a conventional oil-in-water cream. The patch was found to enable to prolong the skin permeation of vitamin A, whereas the cream showed an initial burst skin absorption. The relative vitamin A bioavailability of the patch was about 76.9%, compared with that of the cream. Patches were less irritable to skin than the cream when the same amount of vitamin A was loaded. The lower skin irritancy might be due to the sustained release of vitamin A from the patch matrix. Silicon replica analysis was carried out as a clinical study to quantify the effects of the vitamin A patch on cutaneous relief. Repeated application of vitamin A-loaded patches onto crow's feet wrinkles for 12 weeks resulted in a reduction of the total surface area and the length of the wrinkles by up to 23% and 17%, respectively, without irritation. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC INDUSTRIAL ENGINEERING CHEMISTRY | - |
dc.subject | SOLID LIPID NANOPARTICLES | - |
dc.subject | IN-VITRO | - |
dc.subject | SKIN-PERMEATION | - |
dc.subject | RETINOIC ACID | - |
dc.subject | DRUG-RELEASE | - |
dc.subject | TOPICAL USE | - |
dc.subject | DERMATOLOGY | - |
dc.subject | STABILITY | - |
dc.title | Poly(acrylate-co-vinylacetate) adhesive patch for sustained dermal delivery of vitamin A | - |
dc.type | Article | - |
dc.identifier.wosid | 000181866100007 | - |
dc.identifier.scopusid | 2-s2.0-1542663664 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.beginningpage | 153 | - |
dc.citation.endingpage | 158 | - |
dc.citation.publicationname | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.contributor.localauthor | Nam, YoonSung | - |
dc.contributor.nonIdAuthor | Kim, JW | - |
dc.contributor.nonIdAuthor | Han, SH | - |
dc.contributor.nonIdAuthor | Chang, IS | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | patch | - |
dc.subject.keywordAuthor | vitamin A | - |
dc.subject.keywordAuthor | dermal delivery | - |
dc.subject.keywordAuthor | sustained release | - |
dc.subject.keywordAuthor | skin irritation | - |
dc.subject.keywordPlus | SOLID LIPID NANOPARTICLES | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | SKIN-PERMEATION | - |
dc.subject.keywordPlus | RETINOIC ACID | - |
dc.subject.keywordPlus | DRUG-RELEASE | - |
dc.subject.keywordPlus | TOPICAL USE | - |
dc.subject.keywordPlus | DERMATOLOGY | - |
dc.subject.keywordPlus | STABILITY | - |
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