DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Seungmin | ko |
dc.contributor.author | Lee, Daeyoup | ko |
dc.contributor.author | Gwack, Yousang | ko |
dc.contributor.author | Min, Hyesun | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.date.accessioned | 2013-03-04T15:18:02Z | - |
dc.date.available | 2013-03-04T15:18:02Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2003-03 | - |
dc.identifier.citation | JOURNAL OF GENERAL VIROLOGY, v.84, pp.665 - 676 | - |
dc.identifier.issn | 0022-1317 | - |
dc.identifier.uri | http://hdl.handle.net/10203/83046 | - |
dc.description.abstract | Kaposi's sarcoma-associated herpesvirus (KSHV) is a human gammaherpesvirus related to Epstein-Barr virus (EBV) and herpesvirus saimiri. KSHV open reading frame K8 encodes a basic region-leucine zipper protein of 237 aa. that homodimerizes. K8 shows significant similarity to the EBV immediate-early protein Zta, a key regulator of EBV reactivation and replication. In this study, a carboxyl-terminal deletion mutant of K8, K8(1-115), that had strong transactivating properties was found. Screening using transcriptionally inactive K8(1-75) showed that K8 interacts and co-localizes with hSNF5, a cellular chromatin-remodelling factor, both in vivo and in vitro. This interaction requires aa 48-183 of hSNF5 and 1-75 of K8. In a yeast expression system, the ability of K8 and K8(1-115) to activate transcription requires the presence of SNF5, the yeast homologue of hSNF5. These data suggest a mechanism by which the SWI-SNF complex is recruited to specific genes. They also suggest that K8 functions as a transcriptional activator under specific conditions and that its transactivation activity requires its interaction with the cellular chromatin remodelling factor hSNF5. | - |
dc.language | English | - |
dc.publisher | SOC GENERAL MICROBIOLOGY | - |
dc.subject | EPSTEIN-BARR-VIRUS | - |
dc.subject | SWI-SNF COMPLEX | - |
dc.subject | SWI/SNF COMPLEX | - |
dc.subject | BZIP PROTEIN | - |
dc.subject | INTEGRASE INTERACTOR-1 | - |
dc.subject | VIRAL REPLICATION | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | EXPRESSION | - |
dc.subject | GENE | - |
dc.subject | P53 | - |
dc.title | Kaposi's sarcoma-associated herpesvirus K8 protein interacts with hSNF5 | - |
dc.type | Article | - |
dc.identifier.wosid | 000181237500020 | - |
dc.identifier.scopusid | 2-s2.0-0037371772 | - |
dc.type.rims | ART | - |
dc.citation.volume | 84 | - |
dc.citation.beginningpage | 665 | - |
dc.citation.endingpage | 676 | - |
dc.citation.publicationname | JOURNAL OF GENERAL VIROLOGY | - |
dc.contributor.localauthor | Lee, Daeyoup | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Hwang, Seungmin | - |
dc.contributor.nonIdAuthor | Gwack, Yousang | - |
dc.contributor.nonIdAuthor | Min, Hyesun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | EPSTEIN-BARR-VIRUS | - |
dc.subject.keywordPlus | SWI-SNF COMPLEX | - |
dc.subject.keywordPlus | SWI/SNF COMPLEX | - |
dc.subject.keywordPlus | BZIP PROTEIN | - |
dc.subject.keywordPlus | INTEGRASE INTERACTOR-1 | - |
dc.subject.keywordPlus | VIRAL REPLICATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | P53 | - |
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