DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Taegun | ko |
dc.contributor.author | Lee, Daeyoup | ko |
dc.contributor.author | Shim, Young Sam | ko |
dc.contributor.author | Angell, Jon E. | ko |
dc.contributor.author | Chidambaram, Natesa V. | ko |
dc.contributor.author | Kalvakolanu, Dhananjaya V. | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.date.accessioned | 2013-03-04T15:13:56Z | - |
dc.date.available | 2013-03-04T15:13:56Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2002-07 | - |
dc.identifier.citation | JOURNAL OF VIROLOGY, v.76, no.17, pp.8797 - 8807 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.uri | http://hdl.handle.net/10203/83040 | - |
dc.description.abstract | Kaposi's sarcoma-associated herpesvirus (KSHV) plays a significant role in the development of Kaposi's sarcoma, primary effusion lymphoma, and some forms of multicentric Castleman's disease. The KSHV open reading frame K9 encodes the viral interferon (IFN) factor 1 (vIRF1), which downregulates IFN- and IRF-mediated transcriptional activation, and leads to cellular transformation in rodent fibroblasts and induction of tumors in nude mice. Using the yeast two-hybrid assay, we identified genes associated with retinoid-IFN-induced mortality-19 (GRIM19), which interacts directly with vIRF1, both in vivo and in vitro. The N-terminal region of vIRF1 is required for binding GRIM19. Colocalization of vIRF1 and GRIM19 was observed in 293T cells. The vIRF1 protein deregulates GRIM19-induced apoptosis in the presence of IFN/all-trans-retinoic acid (RA) and inhibits IFN/RA-induced cell death. Another DNA tumor viral protein, human papillomavirus type 16 E6, also binds GRIM19, suggesting that this is a general target of viral proteins. Our results collectively indicate that vIRF1 modulates IFN/RA-cell death signals via interactions with GRIM19. | - |
dc.language | English | - |
dc.publisher | Amer Soc Microbiology | - |
dc.subject | HUMAN-PAPILLOMAVIRUS TYPE-16 | - |
dc.subject | RETINOIC ACID | - |
dc.subject | DNA-SEQUENCES | - |
dc.subject | THIOREDOXIN REDUCTASE | - |
dc.subject | TUMOR-SUPPRESSOR | - |
dc.subject | BINDING PROTEIN | - |
dc.subject | T-ANTIGEN | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | APOPTOSIS | - |
dc.subject | P300 | - |
dc.title | Viral interferon regulatory factor 1 of Kaposis sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death | - |
dc.type | Article | - |
dc.identifier.wosid | 000177334900031 | - |
dc.identifier.scopusid | 2-s2.0-0036333658 | - |
dc.type.rims | ART | - |
dc.citation.volume | 76 | - |
dc.citation.issue | 17 | - |
dc.citation.beginningpage | 8797 | - |
dc.citation.endingpage | 8807 | - |
dc.citation.publicationname | JOURNAL OF VIROLOGY | - |
dc.contributor.localauthor | Lee, Daeyoup | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Seo, Taegun | - |
dc.contributor.nonIdAuthor | Shim, Young Sam | - |
dc.contributor.nonIdAuthor | Angell, Jon E. | - |
dc.contributor.nonIdAuthor | Chidambaram, Natesa V. | - |
dc.contributor.nonIdAuthor | Kalvakolanu, Dhananjaya V. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HUMAN-PAPILLOMAVIRUS TYPE-16 | - |
dc.subject.keywordPlus | RETINOIC ACID | - |
dc.subject.keywordPlus | DNA-SEQUENCES | - |
dc.subject.keywordPlus | THIOREDOXIN REDUCTASE | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.subject.keywordPlus | T-ANTIGEN | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | P300 | - |
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