DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Ssang-Goo | ko |
dc.contributor.author | Kim, Jin Woo | ko |
dc.contributor.author | Lee, Yong Hee | ko |
dc.contributor.author | Hwang, Hyun Sub | ko |
dc.contributor.author | Kim, Mi-Sung | ko |
dc.contributor.author | Ryoo, Kanghyun | ko |
dc.contributor.author | Kim, Myung Jin | ko |
dc.contributor.author | Noh, Kyung Tae | ko |
dc.contributor.author | Kim, Eun Kyung | ko |
dc.contributor.author | Cho, Jun-Ho | ko |
dc.contributor.author | Yoon, Kyoung Wan | ko |
dc.contributor.author | Cho, Eun-Gyung | ko |
dc.contributor.author | Park, Hee-Sae | ko |
dc.contributor.author | Chi, Sung Wook | ko |
dc.contributor.author | Lee, Min-Jae | ko |
dc.contributor.author | Kang, Sang Sun | ko |
dc.contributor.author | Ichijo, Hidenori | ko |
dc.contributor.author | Choi, Eui-Ju | ko |
dc.date.accessioned | 2013-03-04T14:52:03Z | - |
dc.date.available | 2013-03-04T14:52:03Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2003-10 | - |
dc.identifier.citation | JOURNAL OF CELL BIOLOGY, v.163, pp.71 - 81 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.uri | http://hdl.handle.net/10203/82994 | - |
dc.description.abstract | Diverse stimuli initiate the activation of apoptotic signaling pathways that often causes nuclear DNA fragmentation. Here, we report a new antiapoptotic protein, a caspase-activated DNase (CAD) inhibitor that interacts with ASK1 (CIIA). CIIA, by binding to apoptosis signal-regulating kinase 1 (ASKI), inhibits oligomerization-induced ASK1 activation. CIIA also associates with CAD and inhibits the nuclease activity of CAD without affecting caspase-3-mediated ICAD cleavage. Overexpressed CIIA reduces H2O2- and tumor necrosis factor-a-induced apoptosis. CIIA antisense oligonucleotides, which abolish expression of endogenous CIIA in murine L929 cells, block the inhibitory effect of CIA on ASK1 activation, deoxyribonucleic acid fragmentation, and apoptosis. These findings suggest that CIIA is an endogenous antagonist of both ASK1 -.and CAD-mediated signaling. | - |
dc.language | English | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.subject | SIGNAL-REGULATING KINASE-1 | - |
dc.subject | DNA FRAGMENTATION FACTOR | - |
dc.subject | CASPASE-ACTIVATED DNASE | - |
dc.subject | N-TERMINAL KINASE | - |
dc.subject | MAMMALIAN-CELLS | - |
dc.subject | MAP KINASES | - |
dc.subject | APOPTOSIS | - |
dc.subject | INHIBITOR | - |
dc.subject | STRESS | - |
dc.subject | TRANSDUCTION | - |
dc.title | Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities | - |
dc.type | Article | - |
dc.identifier.wosid | 000185956800007 | - |
dc.identifier.scopusid | 2-s2.0-0142027916 | - |
dc.type.rims | ART | - |
dc.citation.volume | 163 | - |
dc.citation.beginningpage | 71 | - |
dc.citation.endingpage | 81 | - |
dc.citation.publicationname | JOURNAL OF CELL BIOLOGY | - |
dc.identifier.doi | 10.1083/jcb.200303003 | - |
dc.contributor.localauthor | Kim, Jin Woo | - |
dc.contributor.nonIdAuthor | Cho, Ssang-Goo | - |
dc.contributor.nonIdAuthor | Lee, Yong Hee | - |
dc.contributor.nonIdAuthor | Hwang, Hyun Sub | - |
dc.contributor.nonIdAuthor | Kim, Mi-Sung | - |
dc.contributor.nonIdAuthor | Ryoo, Kanghyun | - |
dc.contributor.nonIdAuthor | Kim, Myung Jin | - |
dc.contributor.nonIdAuthor | Noh, Kyung Tae | - |
dc.contributor.nonIdAuthor | Kim, Eun Kyung | - |
dc.contributor.nonIdAuthor | Cho, Jun-Ho | - |
dc.contributor.nonIdAuthor | Yoon, Kyoung Wan | - |
dc.contributor.nonIdAuthor | Cho, Eun-Gyung | - |
dc.contributor.nonIdAuthor | Park, Hee-Sae | - |
dc.contributor.nonIdAuthor | Chi, Sung Wook | - |
dc.contributor.nonIdAuthor | Lee, Min-Jae | - |
dc.contributor.nonIdAuthor | Kang, Sang Sun | - |
dc.contributor.nonIdAuthor | Ichijo, Hidenori | - |
dc.contributor.nonIdAuthor | Choi, Eui-Ju | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | apoptosis signal-regulating kinase 1 | - |
dc.subject.keywordAuthor | caspase-activated DNase | - |
dc.subject.keywordAuthor | stress-activated protein kinase | - |
dc.subject.keywordAuthor | c-Jun NH2-terminal kinase | - |
dc.subject.keywordPlus | SIGNAL-REGULATING KINASE-1 | - |
dc.subject.keywordPlus | DNA FRAGMENTATION FACTOR | - |
dc.subject.keywordPlus | CASPASE-ACTIVATED DNASE | - |
dc.subject.keywordPlus | N-TERMINAL KINASE | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | MAP KINASES | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
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